Fig. 3: Ketamine EEG effects segregate from those of AlloP and GABAAR PAMs.
From: Non-sedative cortical EEG signatures of allopregnanolone and functional comparators
A Representative spectrogram showing time course of decrease in beta in frontal EEG (top) and increase in high-range gamma power in parietal EEG (bottom) following ketamine injection, black lines represent vehicle and drug injection, horizontal white lines indicate active segments used for further analysis, white overlay is motion detected from accelerometer. B Ketamine effects on frontal (left) and parietal (right) EEG oscillations during active wake. There were decreases in beta frequency range and increase in mid-gamma power. Two-way repeated measures ANOVA showed drug X frequency interaction for frontal (F(198, 800) = 7.743, p < 0.0001) and parietal (F(198, 800) = 13.63, p < 0.0001) EEG. Horizontal lines indicate difference from vehicle spectra based on Dunnett’s multiple comparisons. C Theta frequency peak in parietal EEG did not differ between vehicle and drug treatments. One-way ANOVA failed to detect main effect of drug treatment (F(1.538,6.153) = 2.990, p = 0.1285).
