Fig. 4: AlloP and comparators: Changes to active wake EEG.
From: Non-sedative cortical EEG signatures of allopregnanolone and functional comparators
A Drug effects on frontal electrode active wake power spectra normalized to vehicle injection. Two-way ANOVA shows frequency X drug interaction (F(297,1800) = 17.75, p < 0.0001). B Drug-induced frontal EEG band power changes. Two-way ANOVA shows frequency band X drug interaction (F (12, 90) = 17.33, p < 0.0001). AlloP was treated as a standard to which other drugs were compared. AlloP differed from ketamine in alpha (p = 0.0405), beta (p < 0.0001) and gamma (p < 0.0001) bands. AlloP differed in beta from pentobarbital (p < 0.0001). C Drug-induced changes on gamma sub-bands of frontal EEG. Two-way ANOVA revealed frequency band X drug interaction (F (3,36) = 86.86 p < 0.0001). Dunnett’s multiple comparisons showed AlloP vs. ketamine (p < 0.0001) and AlloP vs. diazepam (p = 0.0078) differences in low gamma sub-band, and AlloP vs ketamine (p < 0.0001) and AlloP vs. diazepam (p = 0.0051). D Drug effects on parietal electrode active wake power spectra normalized to vehicle injection. Two-way ANOVA shows frequency X drug interaction (F(297,1800) = 16.97, p < 0.0001). E Drug-induced parietal EEG band power changes. Two-way ANOVA revealed frequency band X drug interaction (F (12,90) = 11.04 p < 0.0001). Dunnett’s multiple comparisons showed AlloP vs. ketamine difference in theta (p = 0.0486), beta (p < 0.0001), and gamma (p < 0.0001). F Drug-induced changes on gamma sub-bands of parietal EEG. Two-way ANOVA revealed frequency band X drug interaction (F (3,36) = 86.89, p < 0.0001). Dunnett’s multiple comparisons revealed AlloP vs. Ketamine difference in low (p < 0.0001) and high (p < 0.0001) gamma. Horizontal lines in A, D show significant difference compared to AlloP from Dunnett’s multiple comparisons test. AlloP – red, pentobarbital – blue, diazepam – green, ketamine – purple.
