Table 1 Demographic, intelligence, radiochemistry, behavioral, and current medication information.

From: In vivo translocator protein in females with autism spectrum disorder: a pilot study

 

Scan 1

Scan 2

 

ASD (N = 12)

CON (N = 10)

p value

ASD (N = 4)

CON (N = 5)

p value

Demographics

    Age (years)

25.33 (5.88),

Range: 19–37

25.70 (4.62),

Range: 20–37

0.62

27.00 (3.92),

Range: 22–31

27.60 (5.6),

Range: 23–37

0.95

    Sex

100% female

100% female

 

100% female

100% female

 

    Gender (F/M)

11/1

10/0

>0.99

4/0

5/0

>0.99

    Race (White/Asian/Black)

11/1/0

7/2/1

0.36

4/0/0

3/1/1

0.36

    Ethnicity (Hispanic/Non-Hispanic)

0/12

2/8

0.19

0/4

1/4

>0.99

    TSPO genotype (C/C / C/T)

6/6

5/5

>0.99

2/2

3/2

>0.99

    Body mass index

26.49 (5.03),

Range: 18.90–35.70

23.2 (3.12),

Range: 23.40–37.50

0.06

28.25 (6.58),

Range: 19.60–27.80

25.82 (2.63),

Range: 22.60–28.40

0.60

Intelligence

    SB-5 ABIQ

90.83 (25.36),

Range: 50–124

101.80 (11.33),

Range: 85–118

0.53

73.75 (17.73),

Range: 61–100

98.80 (12.30),

Range: 85–115

<0.05

Radiochemistry measures

    Injected dose (mCi)

14.15 (1.00),

Range: 11.20–15.10

14.13 (0.86),

Range: 11.80–14.83

0.91

14.51 (0.34),

Range: 14.13–14.91

13.77 (1.25),

Range: 11.95–14.82

0.51

    Molar activity (mCi/nmol)

1.16 (0.21),

Range: 0.77–1.49

1.49 (0.65),

Range: 0.42–2.53

0.16

1.32 (0.21),

Range: 1.13–1.57

1.36 (0.22),

Range: 1.06–1.63

0.90

    Injected mass (µg)

4.38 (0.93),

Range: 3.24–6.57

4.25 (2.92),

Range: 1.91–11.99

0.20

3.89 (0.66),

Range: 3.12–4.60

3.62 (0.88),

Range: 2.78–4.88

0.73

Behavioral measures

    ADOS-2 total score (social affect + restrictive and repetitive behavior)

16.00 (5.50),

Range: 9–24,

N = 11

N/A

N/A

16.25 (6.40),

Range: 11–24

N/A

N/A

    ADOS-2 social affect subscale score

12.18 (4.47),

Range: 7–19,

N = 11

N/A

N/A

12.25 (4.65),

Range: 8–18

N/A

N/A

    ADOS-2 restrictive and repetitive behavior subscale score

3.82 (1.66),

Range: 1–6,

N = 11

N/A

N/A

4.00 (1.83),

Range: 2–6

N/A

N/A

    ADI-R total score

40.5 (10.80),

Range: 23–60,

N = 11

N/A

N/A

48.50 (10.79),

Range: 37–60

N/A

N/A

Current medication

    Atypical antipsychotics

3

0

N/A

0

0

N/A

    Antidepressants

7

0

N/A

2

0

N/A

    Anxiolytics

4

0

N/A

1

0

N/A

    Anticonvulsants

3

0

N/A

1

0

N/A

    Stimulants

2

0

N/A

0

0

N/A

  1. p values were determined by Mann–Whitney U tests for all except sex, gender, race, and TSPO genotype for which a Fisher’s exact test was used. Values are reported as mean (standard deviation). The ADOS-2 social affect score ranges from 0 to 20, and the ADOS-2 restrictive and repetitive behavior score ranges from 0 to 10, with higher scores indicating more severe symptoms. The ADI-R total score is the sum of the social, communication, and restrictive, repetitive, and stereotyped behavior subscores.
  2. ASD autism spectrum disorder, CON control, N number, TSPO translocator protein, SB-5 ABIQ Stanford Binet Intelligence Scales, Fifth Edition, abbreviated battery intelligence quotient, ADOS-2 Autism Diagnostic Observation Schedule, Second Edition, ADI-R Autism Diagnostic Interview-Revised, N/A not applicable.
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