Fig. 2: Dose-finding experiment in the food intake paradigm. | Neuropsychopharmacology

Fig. 2: Dose-finding experiment in the food intake paradigm.

From: GLP-1 receptor agonist exenatide uncouples food intake from hedonic and anticipatory regulation in non-human primates: insights from an operant meal schedule paradigm

Fig. 2

Dose-dependent effects of Ex on food consumption (A) and on total daily energy intake (B). Effects of 1, 5 or 20 µg/kg Ex (x axis) on food consumption (y axis on A) in S1 (upper panel) and S2 (lower panel) and daily energy intake (y axis on B) of the two-session food intake paradigm compared to Vehicle control days (Vehicle, *: p < 0.05,**: p < 0.01) and no-treatment Baseline days (Baseline, #: p < 0.05, ##: p < 0.01). P-values are Dunnett-corrected for the 3 comparisons within each analysis. Colours indicate individual animals, points correspond to data from one session on A and one day on B. Black points and whiskers are condition averages and s.e.m. across animals, with the 6 Baseline and 3 Vehicle days shown separately. On the y axis of panel B inward pointing ticks show the daily energy intake recommendation for each animal (colour-coded) based on their current weight. On B, ® markers denote significant differences from nutritional recommendation values (®: p < 0.05, ®®: p < 0.01).

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