Fig. 1: Effect of muscimol-baclofen (M + B) inactivation of DMS and medial OFC on oxycodone seeking after electric barrier-induced voluntary abstinence.
From: Role of dorsal striatum circuits in relapse to opioid seeking after voluntary abstinence
A Experimental timeline. B Injector tip placement in the DMS or mOFC. C, E Oxycodone self-administration training (left) and electric barrier-induced voluntary abstinence (right) for DMS or mOFC rats. Data show mean ± SEM of number of infusions and active and inactive lever presses during the training phase. D, F Relapse test. Data show mean ± SEM number of active lever presses during the 90-min test sessions (left) or 30-min bin timecourse (right) after saline or muscimol-baclofen (50 + 50 ng per side) injection into D DMS or F medial OFC. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05. DMS: n = 9 to 12 rats per dose. mOFC: n = 6 to 13 rats per dose. DMS dorsomedial striatum. mOFC medial orbitofrontal cortex. M + B muscimol-baclofen.
