Fig. 3: The CSDS animals demonstrated chronically increased anhedonia and consistent anxious-like set of behaviors during elevated plus maze (EPM) and exploration of the open field arena. | Neuropsychopharmacology

Fig. 3: The CSDS animals demonstrated chronically increased anhedonia and consistent anxious-like set of behaviors during elevated plus maze (EPM) and exploration of the open field arena.

From: Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice

Fig. 3

A, B The female urine sniffing test (FUST) revealed significant association of shorter sniffing time in the CSDS group during both instances of testing (p < 0.001) (stress effect: #=p < 0.05, ##=p < 0.01, ###=p < 0.001, ####=p < 0.0001). C Overall animals subjected to the CSDS demonstrated significantly decreased preference for the open arms (p < 0.01) of the EPM. D−G In the open field paradigm, general effect of stress (p < 0.05) was observed on almost all of the behavioral parameters except huddle. The significantly increased duration of looking around (p < 0.05) in the CSDS animals, can be interpreted as an indicator of anxious-like pattern and suggest a reduced exploratory behavior of these animals. No significant differences were observed on the level of genotype. H The speed parameter was significantly decreased in the CSDS group, regardless of genotype (p < 0.05). I The overall exploratory index of the open field arena did not show any differences between the groups.

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