Fig. 4: Significant differences in individual and social behaviors between transgenic animals in the CSDS condition arise, when novel CD1 is introduced in the social interaction task. | Neuropsychopharmacology

Fig. 4: Significant differences in individual and social behaviors between transgenic animals in the CSDS condition arise, when novel CD1 is introduced in the social interaction task.

From: Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice

Fig. 4

A–F The majority of the social behavioral parameters were overall significantly decreased in the CSDS animals (stress effect: #=p < 0.05, ##=p < 0.01, ###=p < 0.001, ####=p < 0.0001, genotype effect: *=p < 0.05, **=p < 0.01). G–J The individual parameters marked a significant decrease in the CSDS group. With emerging genotype differences in looking around and huddling behaviors (p < 0.05) K Overall impact of stress was again seen for speed parameter (p < 0.05), with the CRHfkbp5−/− animals moving the least of all the depicted groups (p < 0.05). L An exploratory index confirmed the overall effect of stress and within the CSDS group also indicated a significant genotype difference, with the CSDS CRHfkbp5−/− animals demonstrating significantly the least set of active exploratory behaviors in the arena with a non-aggressive CD1 animal. M The social interaction score solidified the effect of stress, by depicting the overall decreased social contact of the CSDS animals with the novel CD1 animal (p < 0.05).

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