Fig. 5: The Protein-Protein Interaction (PPi) network illustrating the comprehensive interconnections among genes closely linked to the top 50 significantly hypermethylated and 50 hypomethylated sites across the genome in the contexts of depression and suicide history.
From: Genome-wide methylome-based molecular pathologies associated with depression and suicide
The hub genes connecting each small subnetwork under a central network have been shown with a larger circle for each individual analysis. A The PPi network is constructed based on genes identified in the comparison between C vs. MDD+/−S. B PPi network generated using genes derived from the comparison between C vs. MDD−S. C PPi network created using genes identified in the comparison between C vs. MDD+S. D The PPi network was constructed based on genes derived from the MDD−S vs. MDD+S comparison.
