Fig. 1: Safety parameters, subjective high and drug concentrations in every treatment condition.

Mean (SE) ratings of subjective high and mean (SD) 3-MMC serum concentration as a function of time after dosing are shown in the upper row. The lower rows show mean (SE) vital signs (heart rate, systolic and diastolic blood pressure, temperature) throughout each treatment condition (B=baseline); A * denotes a significant (p < 0.05) contrast between 3-MMC and placebo across all time points, with the color of the * representing the 3-MMC dose level.