Table 1 Schedule of safety and cognitive pharmacodynamic measures throughout a treatment day.

From: Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study

 

Events

Time after drug administration (Hours)

  

B

0

   

1

   

2

   

3

   

4

   

5

  
 

Drug screen

*

                       
 

Breakfast

*

                       
 

Treatment

 

*

                      

Vital signs

BS

*

*

*

*

*

*

 

*

 

*

   

*

   

*

   

*

  

VS

*

*

*

*

*

*

 

*

 

*

   

*

   

*

   

*

  

AE

                       

*

Lab safety

*

                      

*

Neurocognition

DSST

  

*

      

*

       

*

      

CTT

   

*

 

*

   

*

   

*

   

*

   

*

  

DAT

   

*

     

*

           

*

  

SMT

      

*

                 

SST

     

*

       

*

          

MFFT

           

*

            
 

Lunch

                 

*

      

Questionnaires

High

*

 

*

*

 

*

 

*

 

*

   

*

   

*

   

*

  

SDRQ

  

*

  

*

               

*

  

CADSS

      

*

              

*

  

Bowdle

       

*

             

*

  

Appetite

*

                  

*

    
  1. BS blood sample, VS vital signs, AE adverse events, DSST digit symbol substitution task, CTT critical Tracking Task, DAT divided attention task, SMT spatial memory task, SST stop signal task, MFFT matching familiar figures task, High visual analogue scale (subjective high), CADSS clinician administered dissociative states scales, SDRQ sensitivity to drug reinforcement questionnaire, B baseline.
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