Fig. 4: P11-KO mice display increased DG but reduced BLA volumes.
From: A molecular mechanism mediating clozapine-enhanced sensorimotor gating
A Schematic depiction of hypothesis and experimental design. B Heatmap showing the expression of p11 throughout the brain. C Whole brain MR template showing the regions with volume changes in color (red-increases, blue-decreases) in p11-KO compared to WT mice. Voxelwise differences data are displayed on the study-specific template image using the dual coding approach: differences are mapped to color hue, and associated p-values are mapped to color transparency. Family-wise error rate controlled p > 0.5 in areas with completely transparent colour overlay. Contours delineate statistically (adjusted p < 0.05) significant difference. Sample sizes: WT mice: n = 10, males: n = 5, females: n = 5; p11-KO mice: n = 10, males: n = 5, females: n = 5. MRI magnetic resonance imaging, DMV/XII dorsal motor nucleus of vagus/hypoglossal nerve nucleus, IO inferior olive, VII facial motor nucleus, DR dorsal raphe, CA1 cornu ammonis 1, L5a cortical layer 5a, BLA basolateral amygdala, DG dentate gyrus.
