Table 2 Drug effects on sustained attention, working memory, self-reported sleep quality, post-awakening sleepiness, and affective state.
VARIABLES | PLACEBO MEAN ± SD | PLA-TRA P-VALUE | TRAZODONE MEAN ± SD | TRA-GHB P-VALUE | GHB MEAN ± SD | PLA-GHB P-VALUE | P-VALUE CONDITION |
|---|---|---|---|---|---|---|---|
PVT, median RT | 307.8 ± 44.2 | 320.3 ± 44.7 | 307.5 ± 33.8 | 0.16 | |||
PVT, lapses | 5.5 ± 7.6 | 0.95 | 7.7 ± 11.8 | <0.001 | 3.4 ± 3.6 | <0.001 | <0.001 |
N-back, median speed | 1.8 ± 0.5 | 1.7 ± 0.5 | 1.8 ± 0.5 | 0.64 | |||
N-back, accuracy | 0.87 ± 0.10 | 0.86 ± 0.11 | 0.88 ± 0.10 | 0.88 | |||
MQ awakening, n | 2.1 ± 1.3 | 1.7 ± 1.4 | 1.6 ± 1.3 | 0.28 | |||
MQ time awake, min | 26.4 ± 50.5 | 18.8 ± 29.8 | 12.7 ± 15.7 | 0.06 | |||
MQ superficial sleep, VAS | 43.6 ± 16.1 | 45.8 ± 22.4 | 38.3 ± 18.7 | 0.38 | |||
MQ undisturbed sleep, VAS | 48.8 ± 16.1 | 55.9 ± 18.7 | 53.0 ± 20.1 | 0.30 | |||
MQ awakening recovery, VAS | 38.6 ± 18.2 | 0.059 | 29.2 ± 20.3 | 0.019 | 41.8 ± 25.8 | 0.64 | 0.043 |
MQ awakening energy, VAS | 45.9 ± 12.5 | 0.086 | 39.6 ± 15.9 | 0.003 | 51.4 ± 17.0 | 0.20 | 0.012 |
KSS pre-sleep, score | 6.2 ± 2.1 | 5.8 ± 1.8 | 5.6 ± 1.9 | 0.26 | |||
KSS post-awakening, score | 6.1 ± 2.1 | 0.028 | 7.3 ± 1.6 | 0.014 | 5.9 ± 2.4 | 0.81 | 0.025 |
PANAS positive evening, score | 22.3 ± 5.2 | 22.3 ± 6.0 | 21.8 ± 6.6 | 0.85 | |||
PANAS negative evening, score | 16.0 ± 5.4 | 16.6 ± 5.7 | 15.1 ± 4.1 | 0.35 | |||
PANAS positive morning, score | 24.0 ± 7.8 | 20.7 ± 8.0 | 23.5 ± 7.5 | 0.15 | |||
PANAS negative morning, score | 14.5 ± 4.7 | 15.0 ± 3.9 | 14.6 ± 3.3 | 0.92 |
