Fig. 5: Transcriptomic pathway analysis demonstrates the diversity of compound treatment responses. | Neuropsychopharmacology

Fig. 5: Transcriptomic pathway analysis demonstrates the diversity of compound treatment responses.

From: Identifying brain-penetrant small-molecule modulators of human microglia using a cellular model of synaptic pruning

Fig. 5

A Activation/Suppression z-score for select IPA Canonical Pathways that are enriched in the DEG of Drug-Seq compounds. B Heatmap of gene differential expression in the Phagosome Formation IPA Pathway by compound. Due to the large number of differentially expressed genes (DEG) in this pathway, only the top DEG are shown (adjusted p-value < 1e−6 and absolute log2 fold-change relative to DMSO >2). Heatmap color represents gene expression level (log2 fold-change relative to DMSO), *indicates a significant DEG with adjusted p-value < 0.1 and absolute log2 fold-change >1. C Relationship between phagosome formation and neuroinflammation pathways for RNA-active compounds exhibiting ≤50% DMSO control phagocytic index, showing the unique position of vorinostat.

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