Fig. 3: The effects of NMDAR antagonists on baseline PFC gamma and low gamma power in WT and GluN2D KO mice. | Neuropsychopharmacology

Fig. 3: The effects of NMDAR antagonists on baseline PFC gamma and low gamma power in WT and GluN2D KO mice.

From: Effects of NMDA receptor antagonists on working memory and gamma oscillations, and the mediating role of the GluN2D subunit

Fig. 3

Power spectral density plots of PCP (A), MK801 (B), R-ket (C) and S-ket (D) occurring in hippocampus of WT and GluN2D-KO mice. PCP and MK-801 significantly increased baseline gamma in WT but not KO mice, while S-ket increased baseline gamma power in both WT and KO mice (E). KO mice show increased baseline gamma power. PCP, MK-801 and S-ket all increased baseline low gamma in the PFC with no effect or interaction with genotype (F) n = 17 WT saline (10 M/7 F), 11 KO saline (8 M/3 F), 17 WT PCP (11 M/6 F), 11 KO PCP (8 M/3 F), 14 WT MK-801 (10 M/4 F), 8 KO MK-801 (6 M/2 F), 15 WT R-ket (9 M/6 F), 12 KO R-ket (9 M/3 F), 13 WT S-ket (9 M/4 F), 16 KO S-ket (11 M/5 F). Data are Mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.0001. Black dots are male mice and grey are females.

Back to article page