Fig. 2: Sitagliptin reduces DPP4 activity, increases DPP4 protein levels and does not alter baseline corticosterone (CORT) levels in male CD1 mice. | Neuropsychopharmacology

Fig. 2: Sitagliptin reduces DPP4 activity, increases DPP4 protein levels and does not alter baseline corticosterone (CORT) levels in male CD1 mice.

From: Sitagliptin as a therapeutic approach for social anxiety disorder: the role of DPP4 and NPY in modulating social fear and comorbid depressive-like behavior in mice

Fig. 2

Mice were administered sitagliptin (Sita; 50 or 100 mg/kg/day) via drinking water (W). a Dipeptidyl dipeptidase 4 (DPP4) activity, b DPP4 protein levels and c baseline CORT levels in serum after 39 days of sitagliptin treatment. Data represent means + SEM and numbers on the bars indicate group sizes. * p < 0.05 versus SFC − /W and SFC + /W.

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