Fig. 3: Functional network analysis of hypermethylated gene transcripts and their role in MDD-related pathways.
From: M6A RNA epitranscriptome dynamics linked to major depressive disorder and suicide risk
A Network connectivity map of the most significantly hypermethylated gene transcripts, with nodes color-coded based on p-value (p ≤ 0.05) changes and edges representing methylation degrees. The functional relationships between gene transcripts serve as background enrichment, highlighting interactions from highest to lowest statistical significance. B A mapped subnetwork is centered around the hub methylated transcripts, which form the core of the functional connectivity network, showing the primary drivers of network functionality based on their interaction patterns. C Sunburst plot depicting the hub gene transcripts and their connection scores, providing a visual representation of their centrality and interaction strengths within the network. D Colored chord plot showing core genes associated with dysregulated KEGG pathways (such as cAMP signaling, dopaminergic signaling, and others) in the dorsolateral prefrontal cortex of MDD subjects, emphasizing the selective functional enrichment of the top methylated transcripts.
