Fig. 5: Rescue of GLT1 expression in the astrocytes of the PVT ameliorates the AIE-induced anxiety-like behavior. | Neuropsychopharmacology

Fig. 5: Rescue of GLT1 expression in the astrocytes of the PVT ameliorates the AIE-induced anxiety-like behavior.

From: Glutamatergic dysfunction of astrocytes in paraventricular nucleus of thalamus contributes to adult anxiety susceptibility in adolescent ethanol exposed mice

Fig. 5

Diagram of experimental schedules (a) and transgenic approach to overexpress GLT1 in the astrocytes of PVT in a cell-type specific manner (b). Diagram and representative expression (c), representative blots (d), and pooled data (e) showing the increased GLT1 expression in the PVT after the AAV-induced Cre expression in the PVT of the Ai9-GLT1 AIE mice. f–k Representative traces (f, i) and pooled data (g, h, j, k) showing that the astrocytic GLT1 rescue in the PVT ameliorates the AIE-induced anxiety-like behavior in the open field test (f–h) and elevated plus maze test (i–k). Female (circles) and male (triangles). Data represented as mean ± SEM. **p < 0.01. Fig. 5a, b, c, f, and i were created using BioRender.com.

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