Abstract
A persisting debate exists on whether physical processes can fully account for the personal experience of reality or whether subjectivity transcends physical processes. However, scientists and philosophers agree that the subjective experience is influenced by information received from the body and the environment, modulated by emotions, concepts, skills, and memories acquired throughout life. Aging compromises aspects of cognition. However, many older adults develop emotion regulation strategies, experience their environment with a positivity bias, and use earlier successful predictive models of reality to compensate. Life events, personalized integration of perspectives of others, and an ever-changing social context, accelerated by the digital revolution, influence the older person’s experience. Loss of loved ones, disability, pain, sensory compromise, the ravages of terminal illness, and the realization of approaching death become part of the older person’s lifeworld. These experiences are integrated into a personal narrative through which older adults interpret reality and satisfy the fundamental need for creating meaning out of one’s life. As we learn about the subjective experience of older adults, we can advance an agenda of research and advocacy that promotes their mental health, increases their participation in social processes, and enables them to contribute to the transgenerational continuity of society to everybody’s benefit.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 13 print issues and online access
$259.00 per year
only $19.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout



Similar content being viewed by others
References
Baars BJ. The conscious access hypothesis: The role of global workspace theory in explaining higher-order cognitive functions. Trends Cogn Sci. 2002;6:455–61.
Bechara A, Damasio H, Tranel D, Damasio AR. The Iowa Gambling Task and the somatic marker hypothesis: some questions and answers. Trends Cogn Sci. 2005;9:159–62.
Sherman MT, Seth AK. Knowing that you know that you know? An extreme-confidence heuristic can lead to above-chance discrimination of metacognitive performance. Neurosci Conscious. 2024;2024:niae020. https://doi.org/10.1093/nc/niae020. May 22.
Edelman GM, Gally JA, Baars BJ. Biology of consciousness. Front Psychol. 2011;2:4 https://doi.org/10.3389/fpsyg.2011.00004.
LeDoux JE, Brown R. A higher-order theory of emotional consciousness. Proc Natl Acad Sci USA. 2017;114:E2016–25. https://doi.org/10.1073/pnas.1619316114.
Chalmers DJ. The Conscious Mind: In Search of a Fundamental Theory. Oxford University Press: Oxford, UK; 1996.
Arthos J. Hermeneutics after Ricoeur. Bloomsbury Academic Press: London, England; 2019.
Taylor CCW. The Atomists: Leucippus and Democritus, University of Toronto Press: Toronto, Canada; 1999.
Warren J. Facing Death: Epicurus and His Critics. Oxford University Press: Oxford, England; 2004.
Huffman CA. Pythagoreanism. In: Zalta EN, editor. The Stanford Encyclopedia of Philosophy; 2001.
Robinson TM. Plato’s Psychology. University of Toronto Press: Toronto, Canada; 1995.
Descartes R. Meditations on First Philosophy. Cottingham J, translator. Cambridge University Press: Cambridge, England; 1996.
Locke, John. An Essay Concerning Human Understanding. Edited by Peter H. Nidditch, Oxford UP, 1975. Originally published 1689.
Freud Sigmund. Formulations Regarding the Two Principles in Mental Functioning. 1911. The Standard Edition of the Complete Psychological Works of Sigmund Freud, edited and translated by James Strachey, vol. 12, Hogarth Press, 1958, pp. 213-26.
Alexopoulos GS. Artificial intelligence and the sense of self of older adults: A philosophy of science perspective. Am J Geriatr Psychiatry. 2024;32:657–62.
Putnam H. Representation and Reality. Massachusetts Institute of Technology Press: Cambridge, MA; 1988.
Putnam H. Renewing Philosophy. Harvard University Press: Cambridge, MA; 2004.
Bostrom N. Superintelligence: Paths, Dangers, Strategies. Oxford University Press: Oxford, England; 2014.
Alexopoulos GS. Artificial Intelligence in Geriatric Psychiatry Through the Lens of Contemporary Philosophy. Am J Geriatr Psychiatry. 2024;32:293–9.
Churchland PM. Matter and consciousness. Massachusetts Institute of Technology Press. Cambridge, MA1988.
Crick F. Koch C. Consciousness and neuroscience. Cereb Cortex. 1998;8:97–107.
Kuhn RL. A landscape of consciousness: Toward a taxonomy of explanations and implications. Prog Biophys Mol Biol. 2024;190:28–169.
Baars BJ. In the theater of consciousness: The workspace of the mind. Oxford University Press: Oxford, England; 1997.
Baars BJ, Franklin S. How conscious experience and working memory interact. Trends Cogn Sci. 2003;7:166–72.
Mitchell KJ. Innate: How the wiring of our brains shapes who we are. Princeton University Press: Princeton, NJ; 2018.
Derrien D, Garric C, Sergent C, Chokron S. The nature of blindsight: implications for current theories of consciousness. Neurosci Conscious. 2022;2022:niab043. https://doi.org/10.1093/nc/niab043.
Dehaene S, Naccache L, Cohen L, Bihan DL, Mangin JF, Poline JB, et al. Cerebral mechanisms of word masking and unconscious repetition priming. Nature Neuroscience. 2001;4:752–8.
Kouider S, Dehaene S. Levels of processing during non-conscious perception: a critical review of visual masking. Philos Trans R Soc Lond B Biol Sci. 2007;362:857–75.
Odegaard B, Knight RT, Lau H. Should a Few Null Findings Falsify Prefrontal Theories of Conscious Perception? J Neurosci. 2017;37:9593–602.
Mofakham S, Liu Y, Hensley A, Saadon JR, Gammel T, Cosgrove ME, et al. Injury to thalamocortical projections following traumatic brain injury results in attractor dynamics for cortical networks. Prog Neurobiol. 2022;210:102215. https://doi.org/10.1016/j.pneurobio.2022.102215.
Bendlin BB, Fitzgerald ME, Ries ML, Xu G, Kastman EK, Thiel BW, et al. White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three. Dev Neuropsychol. 2010;35:257–77.
Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot JD, et al. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J. Eur J Nucl Med Mol Imaging. 2024;51:1012–22.
Groh J, Simons M. White matter aging and its impact on brain function. Neuron. 2025;113:127–39.
Kelber P, Mittelstädt V, Ulrich R. Interplay of aging and practice in conflict processing: A big-data diffusion-model analysis. Psychol Aging. 2025;40:66–85.
Rizzo R, Knight SP, Davis JRC, Newman L, Duggan E, Kenny RA, et al. Longitudinal Study on Sustained Attention to Response Task (SART): Clustering Approach for Mobility and Cognitive Decline. Geriatrics (Basel). 2022;7:51 https://doi.org/10.3390/geriatrics7030051.
İlkmen YS, Soncu Büyükişcan E. The Relationship Between Executive Functions, Self-Reflection, and Insight Across Adulthood. Exp Aging Res. 2024;28:1–14.
Park DC, Reuter-Lorenz P. The adaptive brain: Aging and neurocognitive scaffolding. Annual Review of Psychology. 2009;60:173–96.
Reuter-Lorenz PA, Park DC. Cognitive aging and the life course: A new look at the Scaffolding theory. Curr Opin Psychol. 2024;56:101781. https://doi.org/10.1016/j.copsyc.2023.101781.
Smith GS. Aging and neuroplasticity. Dialogues Clin Neurosci. 2013;15:3–5.
Mora F. Successful brain aging: plasticity, environmental enrichment, and lifestyle. Dialogues Clin Neurosci. 2013;15:45–52.
Ricoeur P. Oneself as Another. University of Chicago Press: Chicago, IL; 1992
Chang H, Do Y, Ahn J. Digital Storytelling as an Intervention for Older Adults: A Scoping Review. Int J Environ Res Public Health. 2023;20:1344 https://doi.org/10.3390/ijerph20021344.
Merleau-Ponty M. The World of Perception. In Magill FN editor. Masterpieces of World Philosophy. New York, NY: Harper Collins Publishers, 1990. p. 619-27.
Alexopoulos GS. Facing a Catastrophic Illness: A Perspective from Contemporary Philosophy. Am J Geriatr Psychiatry. 2024;32:1477–83.
Damasio A. The feeling of what happens: Body and emotion in the making of consciousness. Mariner Books: Boston, MA; 2000.
Damasio AR. The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philos Trans R Soc Lond B Biol Sci. 1996;351:1413–20.
Moldakozhayev A, Gladyshev VN. Metabolism, homeostasis, and aging. Trends Endocrinol Metab. 2023;34:158–69.
Chen WG, Schloesser D, Arensdorf AM, Simmons JM, Cui C, Valentino R, et al. The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self. Trends Neurosci. 2021;44:3–16.
Ulus G, Aisenberg-Shafran D. Interoception in Old Age. Brain Sci. 2022;12:1398 https://doi.org/10.3390/brainsci12101398.
Mora F, Agnati LF, Fuxe K. An international conference on Brain Plasticity, Aging and Neuropsychiatric disorders hosted by the Ramon Areces Foundation. Preface. J Neural Transm. 2009;116:921–2.
Blanchflower DG, Graham C, Piper A. Happiness and age-resolving the debate. National Institute Economic Review. 2023;263:76–93.
Mammarella N, Di Domenico A, Fairfield B. Aging and the genetic road towards the positivity effect in memory. Exp Gerontol. 2016;82:120–4.
Kalenzaga S, Lamidey V, Ergis AM, Clarys D, Piolino P. The positivity bias in aging: Motivation or degradation? Emotion. 2016;16:602–10. https://doi.org/10.1037/emo0000170.
Ku LC, Lai VT. Use of context in updating affective representations of words in older adults. Biol Psychol. 2025;195:109003. https://doi.org/10.1016/j.biopsycho.2025.109003.
Carstensen LL, DeLiema M. The positivity effect: a negativity bias in youth fades with age. Curr Opin Behav Sci. 2018;19:7–12. https://doi.org/10.1016/j.cobeha.2017.07.009.
Levin F, Fiedler S, Weber B. Positivity effect and decision making in ageing. Cogn Emot. 2021;35:790–804.
Ziaei M, Samrani G, Persson J. Age-related alterations in functional connectivity patterns during working memory encoding of emotional items. Neuropsychologia. 2017;94:1–12.
Gronchi G, Righi S, Pierguidi L, Giovannelli F, Murasecco I, Viggiano MP. Automatic and controlled attentional orienting in the elderly: A dual-process view of the positivity effect. Acta Psychologica. 2018;185:229–34.
Carstensen LL. The influence of a sense of time on human development. Science. 2006;312:1913–5.
Rao RP, Ballard DH. Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. Nat Neurosci. 1999;2:79–87.
Seth AK, Stone JV. The Bayesian brain and its implications for the perception of consciousness. Journal of Consciousness Studies. 2011;18:1–22.
Stone JV, Seth AK. Bayesian models of perception: The role of prior knowledge in perceptual decision making. Proceedings of the Royal Society B: Biological Sciences. 2014;281:20140348 https://doi.org/10.1098/rspb.2014.0348.
Skora LI, Seth AK, Scott RB. Sensorimotor predictions shape reported conscious visual experience in a breaking continuous flash suppression task. Neurosci Conscious. 2021;2021:niab003. https://doi.org/10.1093/nc/niab003.
Tscshantz A, Millidge B, Seth AK, Buckley CL. Hybrid predictive coding: Inferring, fast and slow. PLoS Comput Biol. 2023;19:e1011280 https://doi.org/10.1371/journal.pcbi.1011280.
Seth AK. The role of perception in the construction of consciousness: A controlled hallucination perspective. In The Oxford Handbook of Philosophy and Neuroscience. Oxford University Press: Oxford, England; 2014.
Moran RJ, Symmonds M, Dolan RJ, Friston KJ. The brain ages optimally to model its environment: Evidence from sensory learning over the adult lifespan. PLoS Computational Biology. 2014;10:e1003722. https://doi.org/10.1371/journal.pcbi.1003722.
Zanto TP, Rubens MT, Bollinger J, Gazzaley A. Top-down modulation of visual feature processing: The role of the inferior frontal junction. Neuroimage. 2010;53:736–45.
Stephan KE, Schlagenhauf F, Huys QJM, Raman S, Aponte EA, Brodersen KH, et al. Computational neuroimaging strategies for single patient predictions. Neuroimage. 2017;145:180–99.
Hess TM. The impact of aging on the use of social stereotypes: A developmental perspective. In: The Handbook of Aging and the Social Sciences. Academic Press: Cambridge, MA; 2006. p. 105–22.
Reed AE, Carstensen LL. The theory of socioemotional selectivity: A new perspective on development and aging. In The Oxford Handbook of Developmental Psychology. Oxford University Press; 2012. vol. 2, p. 278–94.
Campbell KL, Hasher L, Thomas RC. Hyper-binding: a unique age effect. Psychol Sci. 2010;21:399–405.
Baltes PB, Baltes MM. Psychological perspectives on successful aging: The model of selective optimization with compensation. In: Baltes PB, Baltes MM, editors. Successful Aging: Perspectives from the Behavioral Sciences. Cambridge University Press: Cambridge, England; 1990. p. 1–34.
Hess TM, Queen TL. Aging and cognitive flexibility: The role of social context. Psychology and Aging. 2005;20:260–73.
Brashier NM, Umanath S, Cabeza R, Marsh EJ. Competing cues: Older adults rely on knowledge in the face of fluency. Psychol Aging. 2017;32:331–7.
Woodruff E, Poltronieri BC, Sousa LPA, de Oliveira YG, Reis MA, Scoriels L, et al. Effects of bottom-up versus top-down digital cognitive training in older adults: A randomized controlled trial. Arch Gerontol Geriatr. 2024;127:105552. https://doi.org/10.1016/j.archger.2024.105552.
Edelman GM, Tononi G. A Universe of Consciousness: How Matter Becomes Imagination. Basic Books: New York, NY; 2000.
Edelman GM, Gally JA. Reentry: a key mechanism for integration of brain function. Front Integr Neurosci. 2013;7:63 https://doi.org/10.3389/fnint.2013.00063.
Edelman GM. Naturalizing consciousness: a theoretical framework. Proc Natl Acad Sci USA. 2003;100:5520–4.
Tononi G. Edelman GM. Consciousness and complexity. Science. 1998;282:1846–51.
Edelman GM. The Remembered Present: A Biological Theory of Consciousness. Basic Books; New Yok, NY; 1989.
Edelman GM. Wider than the Sky: The Phenomenal Gift of Consciousness. Yale University Press: New Haven, CT; 2004.
Barker RM, Read SJ. Perception of the environment: A developmental perspective on the interplay of social context and cognition in older adults. J Gerontol B Psychol Sci Soc Sci. 2020;75:322–30.
Friedman HS, Kern ML. Personality, well-being, and health. Annu Rev Psychol. 2014;65:219–41.
Cohen S, Janicki-Deverts D, Miller GE. Psychological stress and disease. JAMA. 2017;298:1685–7.
Zhao Y, Baird AA. The effects of cognitive training on brain plasticity and cognitive performance: A systematic review. Front Hum Neurosci. 2018;12:181 https://doi.org/10.3389/fnhum.2018.00181.
Feng Y, Li H, Zhu C. Engagement in intellectual activities is associated with increased neural connectivity in older adults: Evidence from functional MRI. Neuroimage. 2020;207:116400. https://doi.org/10.1016/j.neuroimage.2019.116400.
Lambertus M, Geiseler S, Morland C. High-intensity interval exercise is more efficient than medium intensity exercise at inducing neurogenesis. J Physiol. 2024;602:7027–42.
Caruso MG, Nicolas S, Lucassen PJ, Mul JD, O’Leary OF, Nolan YM. Ageing, Cognitive Decline, and Effects of Physical Exercise: Complexities, and Considerations from Animal Models. Brain Plast. 2024;9:43–73.
LeDoux JE. As soon as there was life, there was danger: the deep history of survival behaviors and the shallower history of consciousness. Philos Trans R Soc Lond B Biol Sci. 2022;377:20210292. https://doi.org/10.1098/rstb.2021.0292.
Nolte M, van der Flier WM, Teunissen CE, Damoiseaux JS. Aging effects on amygdala subnuclei: A systematic review and meta-analysis of neuroimaging studies. Neurobiol Aging. 2020;92:80–92.
Fischer AL, Kuhlmann BG. Age-related changes in the amygdala and emotional processing: A focus on amygdala subregions and their functional connectivity. Neurosci Biobehav Rev. 2021;120:103–16.
Bookheimer TH, Ganapathi AS, Iqbal F, Popa ES, Mattinson J, Bramen JE, et al. Beyond the hippocampus: Amygdala and memory functioning in older adults. Behav Brain Res. 2024;471:115112. https://doi.org/10.1016/j.bbr.2024.115112.
Bartsch T, Wulff P. The hippocampus in aging and disease: From plasticity to vulnerability. Neurosci. 2015;309:1–16.
Barker GRI, Warburton EC. When the past interferes with the present: How the hippocampus supports the use of contextual information in decision-making. Curr Opin Behav Sci. 2020;32:1–7.
Dumont JM, Panksepp J. Hippocampal dysfunction and the misinterpretation of safety cues: Implications for anxiety disorders. J Psychiatr Neurosci. 2022;47:23–35.
Miller MA, Wankel LM. Contextual memory and anxiety: The role of the hippocampus in emotional responses to contextual cues. Neurosci Biobehav Rev. 2020;108:493–502.
Fjell AM, Walhovd KB. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21:187–221.
Davis SW, Dennis NA, Buchler NG, Madden DJ. The aging brain and cognition: The role of functional connectivity in cognitive reserve. Neuropsychol Rev. 2018;28:336–52.
McDonough IM, Spreng RN, Turner GR, Schacter DL. Compensatory neural mechanisms in aging: The role of functional connectivity in cognitive performance. Aging Neuropsychol Cogn. 2021;28:1025–44.
Mather M, Sutherland M. Aging and the positivity effect: A review of the evidence and implications for cognitive aging. Curr Dir Psychol Sci. 2011;20:353–7.
Scheibe S, Carstensen LL. Emotional aging: Affective regulation and the role of social context. Emotion. 2010;10:392–401.
Viher PV, Seitz-Holland J, Schulz MS, Kensinger EA, Karmacharya S, Swisher T, et al. More organized white matter is associated with positivity bias in older adults. Brain Imaging Behav. 2024;18:555–65.
Gonzalez ML, Rapp PR. The role of the medial prefrontal cortex in age-related changes in emotional processing: A neuroimaging perspective. Neurosci Biobehav Rev. 2021;120:136–50.
Noh MH, Lee SM, Kim HS, Lee KH. Neural correlates of the positivity effect in older adults: An fMRI study of emotional memory. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2020;27:750–65.
Dolcos F, Iordan AD, Dolcos S. Age-related differences in the engagement of the prefrontal cortex during emotional memory encoding and retrieval. Neurosci Biobehav Rev. 2020;112:497–507.
Carhart-Harris RL, Leech R, Hellyer PJ, Shanahan M, Feilding A, Tagliazucchi E, et al. The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Front Hum Neurosci. 2014;8:20 https://doi.org/10.3389/fnhum.2014.00020.
Keshmiri S. Entropy and the Brain: An Overview. Entropy (Basel). 2020;22:917 https://doi.org/10.3390/e22090917.
Carhart-Harris RL. The entropic brain-revisited. Neuropharmacol. 2018;142:167–78.
Carhart-Harris RL, Friston KJ. REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. Pharmacol Rev. 2019;71:316–44.
Fotenos AF, Mintun MA, Snyder AZ, Morris JC, Buckner RL. Brain Volume Decline in Aging: Evidence for a Relation Between Socioeconomic Status, Preclinical Alzheimer Disease, and Reserve. Arch Neurol. 2008;65:113–20.
Webb CE, Rodrigue KM, Hoagey DA, Foster CM, Kennedy KM. Contributions of White Matter Connectivity and BOLD Modulation to Cognitive Aging: A Lifespan Structure-Function Association Study. Cereb Cortex. 2020;30:1649–61.
Szczupak D, Ljungqvist Brinson L, Kolarcik CL. Brain connectivity, neural networks, and resilience in aging and neurodegeneration. Am J Pathol. 2025; 195, S0002-9440(25)00027-6. https://doi.org/10.1016/j.ajpath.2024.12.014.
Zhang H, Cao P, Mak HKF, Hui ES. The structural-functional-connectivity coupling of the aging brain. Gerosci. 2024;46:3875–87.
Yordanova J, Falkenstein M, Kolev V. Aging alters functional connectivity of motor theta networks during sensorimotor reactions. Clin Neurophysiol. 2024;158:137–48.
Cacciotti A, Pappalettera C, Miraglia F, Rossini PM, Vecchio F. EEG entropy insights in the context of physiological aging and Alzheimer’s and Parkinson’s diseases: a comprehensive review. Gerosci. 2024;46:5537–57.
Wang CH, Moreau D, Yang CT, Tsai YY, Lin JT, Liang WK, et al. Aerobic exercise modulates transfer and brain signal complexity following cognitive training. Biol Psychol. 2019;144:85–98. https://doi.org/10.1016/j.biopsycho.2019.03.012.
Koch C, Massimini M. The consciousness and the brain: Deciphering how the brain codes our thoughts and feelings. Nat Rev Neurosci. 2019;20:407–24.
Chalmers DJ. The Conscious Mind: In Search of a Fundamental Theory. Oxford University Press: Oxford, England; 2020.
Clark A. Surfing Uncertainty: Prediction, Action, and the Embodied Mind. Oxford University Press: Oxford, England; 2021.
Jackson F. Epiphenomenal Qualia. Philos Q. 1982;32:127–36.
Robinson H. The Disconnect Between Knowledge and Experience: Mary’s Room and the Epistemology of Qualia. Philos Psychol. 2009;22:399–413.
Jackson F. Mind and Illusion. In Anthony O’Hear editor. Minds and Persons. Cambridge University Press, R Inst Philos Suppl. 2003; 53:251–71.
Nagel T. What Is It Like to Be a Bat? Philos Rev. 1974;83:435–50.
Nagel T. Mind and Cosmos: Why the Materialist Neo-Darwinian Conception of Nature is Almost Certainly False. Oxford University Press: Oxford, England; 2012.
Alexopoulos GS. Navigating the Last Leg of the Sail. Am J Geriatr Psychiatry. 2025;33:225–7.
Fodor JA. The Language of Thought. Harvard University Press: Cambridge, MA; 1975.
Brentano F. Psychology from an Empirical Standpoint. Translated by Rancurello AC, Terrell DB, McAlister LL, translators. Routledge: London, England; 1995.
Husserl E. Logical Investigations. Findlay JN, translator. Routledge: London, England; 2001.
Fodor JA. The Mind Doesn’t Work That Way: The Scope and Limits of Computational Psychology. MIT Press: Cambridge, MA; 2000.
Chalmers DJ. Facing Up to the Problem of Consciousness. J Consciousness Stud. 1995;2:200–19.
Chalmers DJ. The Character of Consciousness. Oxford University Press: Oxford, England; 2010.
Chalmers DJ. David J. Chalmers. Neuron. 2023;111:3341–3.
Chalmers DJ. The Mind-Body Problem. In: The Blackwell Guide to Philosophy of Mind. Stitch S, editor. Blackwell: Oxford, England; 2002. p. 19–39.
Yablo S. Is conceivability a guide to possibility? Philos Phenomenol Res. 1993;53:1–42.
Patricia Churchland. Touching a Nerve: The Self as Brain. W. W. Norton & Company: New York, NY; 1913.
Chalmers DJ. Naturalistic dualism. In: Velmans M, Schneider S, editors. The Blackwell companion to consciousness. Wiley-Blackwell: London, England; 2007.
Wild CP. The exposome: From concept to utility. Int J Epidemiol. 2012;41:24–32. 2012.
Chung MK, Rappaport SM, Wheelock CE, Nguyen VK, van der Meer TP, Miller GW, et al. Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery. Environ Health Perspect. 2021;129:85001 https://doi.org/10.1289/EHP8327.
Russell B. The Philosophy of Logical Atomism. George Allen and Unwin, Ltd: London, England; 1927.
Russell B. An Inquiry into Meaning and Truth. London: George Allen and Unwin, Ltd: London, England; 1940.
Tononi G, Koch C. Consciousness: here, there and everywhere? Philos Trans R Soc Lond B Biol Sci. 2015;370:20140167 https://doi.org/10.1098/rstb.2014.0167.
Tononi G, Boly M, Massimini M, Koch C. Integrated information theory: from consciousness to its physical substrate. Nat Rev Neurosci. 2016;17:450–61.
Tononi G. Phi: A manifesto for a new science of consciousness. Pantheon Books: New York, NY; 2016.
Tononi G, Sporns O. Measuring information integration. BMC Neurosci. 2003;4:31. https://doi.org/10.1186/1471-2202-4-31.
Flores G, Aguilar-Hernández L, García-Dolores F, Nicolini H, Vázquez-Hernández AJ, Tendilla-Beltrán H. Dendritic spine degeneration: a primary mechanism in the aging process. Neural Regen Res. 2025;20:1696–8.
Buss EW, Corbett NJ, Roberts JG, Ybarra N, Musial TF, Simkin D, et al. Cognitive aging is associated with redistribution of synaptic weights in the hippocampus. Proc Natl Acad Sci USA. 2021;118:e1921481118. https://doi.org/10.1073/pnas.1921481118.
Heuer SE, Nickerson EW, Howell GR, Bloss EB. Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits. Aging Cell. 2024;23:e14033. https://doi.org/10.1111/acel.14033.
Gooijers J, Pauwels L, Hehl M, Seer C, Cuypers K, Swinnen SP. Aging, brain plasticity, and motor learning. Ageing Res Rev. 2024;102:102569. https://doi.org/10.1016/j.arr.2024.102569.
Jauny G, Eustache F, Hinault T. Connectivity dynamics and cognitive variability during aging. Neurobiol Aging. 2022;118:99–105.
Goelman G, Dan R, Bezdicek O, Jech R, Ekstein D. Directed functional connectivity of the default-mode-network of young and older healthy subjects. Sci Rep. 2024;14:4304. https://doi.org/10.1038/s41598-024-54802-6.
Heuninckx S, Wenderoth N, Swinnen SP. Systems neuroplasticity in the aging brain: recruiting additional neural resources for successful motor performance in elderly persons. J Neurosci. 2008;28:91–9.
Yue WL, Ng KK, Liu S, Qian X, Chong JSX, Koh AJ, et al. Differential spatial working memory-related functional network reconfiguration in young and older adults. Netw Neurosci. 2024;8:395–417.
Varela FJ, Thompson E, Rosch E. The Embodied Mind: Cognitive Science and Human Experience. MIT Press: Boston, MA; 1991.
Varela FJ, Shear J. First-person methodologies: What, why, how? J Consciousness Stud. 1999;6:1–14.
Varela FG, Maturana HR, Uribe. r. Autopoiesis: The organization of living systems, its characterization and a model. Biosystems. 1974;5:187–96.
Bianchini F. Autopoiesis of the artificial: from systems to cognition. Biosystems. 2023;230:104936. https://doi.org/10.1016/j.biosystems.2023.104936.
Husserl E. Ideas: General Introduction to a Pure Phenomenology. In: Masterpieces of World Philosophy. Magill FN, editor. Harper Collins Publishers: New York, NY. 1990, p. 502–9.
Varela FJ, Toro A, John ER, Schwartz EL. Perceptual framing and cortical alpha rhythm. Neuropsychologia. 1981;19:675–86.
Varela FJ. Resonant cell assemblies: a new approach to cognitive functions and neuronal synchrony. Biol Res. 1995;28:81–95.
Varela FJ. Neurophenomenology: A methodological remedy for the hard problem. J Consciousness Stud. 1996;3:330–49.
Schwitzgebel E. The unreliability of naïve introspection. Philos Rev. 2008;117:245–73.
Simpson S, Eskandaripour M, Levine B. Effects of Healthy and Neuropathological Aging on Autobiographical Memory: A Meta-Analysis of Studies Using the Autobiographical Interview. J Gerontol B Psychol Sci Soc Sci. 2023;78:1617–24.
Pitts BL, Smith ME, Newberry KM, Bailey HR. Semantic knowledge attenuates age-related differences in event segmentation and episodic memory. Mem Cognit. 2022;50:586–600. https://doi.org/10.3758/s13421-021-01220-y.
Craik FIM. Memory, aging and the brain: Old findings and current issues. Aging Brain. 2023;4:100096. https://doi.org/10.1016/j.nbas.2023.100096.
Cutler RA, Mirjalili S, Pham P, Devulapalli H, Zafar S, Duarte A. Semantic memory space becomes denser with age. Neuropsychologia. 2025;208:109083. https://doi.org/10.1016/j.neuropsychologia.2025.109083.
Wang P, Zhou C, Li HJ. Lifestyle factors associated with episodic memory in middle-aged and older adults: evidence from a 9-year longitudinal study. BMC Public Health. 2024;24:2977. https://doi.org/10.1186/s12889-024-20483-z.
Riemer M, Wolbers T, van Rijn H. Age-related changes in time perception: The impact of naturalistic environments and retrospective judgements on timing performance. Q J Exp Psychol. 2021;74:2002–12.
Jefferies LN, Roggeveen AB, Enns JT, Bennett PJ, Sekuler AB, Di Lollo V. On the time course of attentional focusing in older adults. Psychol Res. 2015;79:28–41.
Wang K, Wang X, Wang Y. Factors, mechanisms and improvement methods of muscle strength loss. Front Cell Dev Biol. 2024;12:1509519. https://doi.org/10.3389/fcell.2024.1509519.
Dyring R, Blonk L. Phenomenologies of aging: an introduction. Cont Philos Rev. 2024;57:537–46.
Aristotle. Nicomachean Ethics. H. Tredennick, J.A.K. Thomson (Trans). Penguin Classics: New York, New York; 2004.
Wittgenstein L. Philosophical Investigations. GEM Anscombe GEM translator. Basil Blackwell: Oxford, England; 1953.
Rorty R. Contingency, Irony, and Solidarity. Cambridge University Press: Cambridge, England; 1989.
Lyotard, JF. The Postmodern Condition. A Report on Knowledge. University of Minnesota Press: Minneapolis, MN; 1984.
Alexopoulos GS. The evolution of Western philosophical concepts on social determinants of mental and medical health. Int Psychogeriatr. 2024;36:1–8.
Lang FR, Carstensen LL. Time counts: Future time perspective, goals, and social relationships. Psychol Aging. 2002;7:125–39.
Liu SH, Weber ES, Manz KE, McCarthy KJ, Chen Y, Schüffler PJ, et al. Assessing the Impact and Cost-Effectiveness of Exposome Interventions on Alzheimer’s Disease: A Review of Agent-Based Modeling and Other Data Science Methods for Causal Inference. Genes. 2024;15:1457 https://doi.org/10.3390/genes15111457.
Visoki E, Moore TM, Zhang X, Tran KT, Ly C, Gatavinš MM, et al. Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts. JAMA Psychiatry. 2024;81:1020–9.
Blanchflower DG. Is happiness U-shaped everywhere? Age and subjective well-being in 145 countries. J Popul Econ. 2021;34:575–624.
Oshio T, Shimizutani S. Well-being paradox: comparing the age-happiness relationship across Japan, China, and the US. JER. 2024;75:547–62.
Carstensen LL, Isaacowitz DM, Charles ST. Taking time seriously. A theory of socioemotional selectivity. Am Psychol. 1999;54:165–81.
Murphy SE, O’Donoghue MC, Blackwell SE, Nobre AC, Browning M, Holmes EA. Increased rostral anterior cingulate activity following positive mental imagery training in healthy older adults. Soc Cogn Affect Neurosci. 2017;12:1950–8.
Lee LO, James P, Zevon ES, Kim ES, Trudel-Fitzgerald C, Spiro A, et al. Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women. Proc Natl Acad Sci USA. 2019;116:18357–62.
Kubzansky L, Boehm J, Segerstrom S. Positive psychological functioning and the biology of health. Soc Personal Psychol Compass. 2015;9:645–60.
Jeste DV, Alexopoulos GS, Blazer DG, Lavretsky H, Sachdev PS, Reynolds CF. Wisdom, Resilience, and Well-Being in Later Life. Annu Rev Clin Psychol. 2024 Dec 2. https://doi.org/10.1146/annurev-clinpsy-081423-031855.
Ochsner KN, Gross JJ. Cognitive Emotion Regulation: Insights from Social Cognitive and Affective Neuroscience. Curr Dir Psychol Sci. 2008;17:153–8.
Isaacowitz DM. What Do We Know About Aging and Emotion Regulation? Perspect Psychol Sci. 2022;17:1541–55.
Park Y, Gordon AM, Mendes WB. Age Differences in Physiological Reactivity to Daily Emotional Experiences. Affect Sci. 2023;4:487–99.
Searle JR. How to study consciousness scientifically. Philos Trans R Soc Lond B Biol Sci. 1998;353:1935–42.
Searle JR. The rediscovery of the mind. MIT Press: Cambridge, MA; 1992.
Tsakiris M, Critchley H. Interoception beyond homeostasis: affect, cognition and mental health. Philos Trans R Soc Lond B Biol Sci. 2016;371:20160002 https://doi.org/10.1098/rstb.2016.0002.
Menon V. 20 years of the default mode network: A review and synthesis. Neuron. 2023;111:2469–87.
Sardella A, Lenzo V, Basile G, Martino G, Quattropani MC. Emotion regulation strategies and difficulties in older adults: A systematic review. Clin Gerontol. 2023;46:280–301.
Park DC, Bischof GN. The aging mind: neuroplasticity in response to cognitive training. Dialogues Clin Neurosci. 2013;15:109–19.
Festa F, Medori S, Macrì M. Move your body, boost your brain: The positive impact of physical activity on cognition across all age groups. Biomed. 2023;11:1765 https://doi.org/10.3390/biomedicines11061765.
Stillman CM, Esteban-Cornejo I, Brown B, Bender CM, Erickson KI. Effects of Exercise on Brain and Cognition Across Age Groups and Health States. Trends Neurosci. 2020;43:533–43.
Firth J, Stubbs B, Vancampfort D, Schuch F, Lagopoulos J, Rosenbaum S, et al. Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis. Neuroimage. 2018;166:230–8.
Loprinzi PD. Objectively measured light and moderate-to-vigorous physical activity is associated with lower depression levels among older US adults. Aging Ment Health. 2013;17:801–5.
Young J, Angevaren M, Rusted J, Tabet N. Aerobic exercise to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 2015;2015:CD005381. https://doi.org/10.1002/14651858.CD005381.pub4.
Chirles TJ, Reiter K, Weiss LR, Alfini AJ, Nielson KA, Smith JC. Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders. J Alzheimers Dis. 2017;57:845–56.
Metzinger T. Being no one: The self-model theory of subjectivity. Massachusetts Institute of Technology Press: Cambridge, MA; 2003.
Mead GH: Mind, Self, and Society. University of Chicago Press: Chicago, IL; 1934.
Frankl, Viktor E. Man’s Search for Meaning. Beacon Press: Boston, MA; 1985.
Dworkin R M. Law’s Empire. Harvard University Press: Cambridge, Mass; 1986.
Meevissen YMC, Peters ML, Alberts HJEM. Become more optimistic by imagining a best possible self: Effects of a two week intervention. J Behav Ther Exp Psychiatry. 2011;42:371–8.
Carver CS, Scheier MF, Segerstrom SC. Optimism. Clin Psychol Rev. 2010;30:879–89.
Santini ZI, Koyanagi A, Tyrovolas S, Mason C, Haro JM. The association between social relationships and depression: a systematic review. J Affect Disord. 2015;175:53–65.
Holwerda TJ, van Tilburg TG, Deeg DJ, Schutter N, Van R, Dekker J, et al. Impact of loneliness and depression on mortality: results from the Longitudinal Ageing Study Amsterdam. Br J Psychiatry. 2016;209:127–34.
Song S, Seo Y, Hwang S, Kim HY, Kim J. Digital Phenotyping of Geriatric Depression Using a Community-Based Digital Mental Health Monitoring Platform for Socially Vulnerable Older Adults and Their Community Caregivers: 6-Week Living Lab Single-Arm Pilot Study. JMIR Mhealth Uhealth. 2024;12:e55842 https://doi.org/10.2196/55842. Jun 17PMID: 38885033.
Broadbent E, Loveys K, Ilan G, Chen G, Chilukuri MM, Boardman SG, et al ElliQ, an AI-Driven Social Robot to Alleviate Loneliness: Progress and Lessons Learned. JAR Life. 202413:22–28.
Sorin V, Brin D, Barash Y, Konen E, Charney A, Nadkarni G, Klang E. Large Language Models and Empathy: Systematic Review. J Med Int Res. 2024. https://pubmed.ncbi.nlm.nih.gov/39661968/.
Elyoseph Z, Refoua E, Asraf K, Lvovsky M, Shimoni Y, Hadar-Shoval D. Capacity of generative AI to interpret human emotions from visual and textual data: Pilot evaluation study. JMIR Mental Health 2024. https://pubmed.ncbi.nlm.nih.gov/38319707/.
Narimisaei J, Naeim M, Imannezhad S, Samian P, Sobhani M. Exploring emotional intelligence in artificial intelligence systems: a comprehensive analysis of emotion recognition and response mechanisms. Annals of medicine and surgery 2024. https://pubmed.ncbi.nlm.nih.gov/39118764/.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
George S. Alexopoulos has served on an advisory board on digital therapeutics and in the speakers bureau of Otsuka Pharmaceuticals.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Alexopoulos, G.S. Consciousness, subjectivity, and aging in western thought. Neuropsychopharmacol. (2026). https://doi.org/10.1038/s41386-026-02321-5
Received:
Revised:
Accepted:
Published:
Version of record:
DOI: https://doi.org/10.1038/s41386-026-02321-5
This article is cited by
-
Neuropsychiatric illness in the later years of life: summary and synthesis
Neuropsychopharmacology (2026)


