Fig. 3: cTBS-induced changes in brain activation and effective connectivity during the UG. | Neuropsychopharmacology

Fig. 3: cTBS-induced changes in brain activation and effective connectivity during the UG.

From: Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial

Fig. 3

A The regions showing brain activity during the offer presentation stage (voxel-level p = 0.001, cluster-level FWE p < 0.05). B The regions showing brain activity modulated by group × time interaction for the interested [unfair-fair] contrasts (voxel-level p = 0.005, >30 voxels). These results did not survive multiple comparisons correction (cluster-level FWE p < 0.05) and should be considered exploratory. C The group mean effective connectivity across all subjects and conditions (Pp > 0.95). These parameters represent the average connectivity during the offer presentation. Overall, the regions showed excitatory influences between each other (yellow blocks) and the self-connections of each region were inhibitory (blue blocks). D The connections, i.e., R.Insula→R.DLPFC and ACC→L.Insula, modulated by group × time effects (Pp > 0.95). E The effective connectivity strengths identified in the interaction effect were plotted in each group and time point. L left, R right, EC effective connectivity, FWE family wise error, Pp posterior probability.

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