Fig. 2: GPAT and insulin resistance. | Nutrition & Diabetes

Fig. 2: GPAT and insulin resistance.

From: Update on glycerol-3-phosphate acyltransferases: the roles in the development of insulin resistance

Fig. 2

Glycerol-3-phosphate acyltransferase 1 and 4 (GPAT1 and GPAT4) overexpression impairs insulin signaling in mice. The increased intermediates by GPAT1 activated the PKCε pathway, and phosphatidic acid (PA) produced by overexpression of GPAT1 and GPAT4 interfere with the insulin signaling and inhibit the association between rictor and the mammalian target of rapamycin (mTOR) as well as mTORC2 (mTOR complex) activity in mice, which resulted in insulin resistance and impaired glucose homeostasis

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