Table 2 Concentrations of glucose, insulin, glucagon, ghrelin, cholecystokinin (CCK), gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

From: Effect of gender on the acute effects of whey protein ingestion on energy intake, appetite, gastric emptying and gut hormone responses in healthy young adults

A

Gender effect

B

Protein-load effect

Men

Women

Average

Control

30 g protein

70 g protein

Average

60min

 Glucose

4.9 ± 0.1

5.3 ± 0.1

  

5.5 ± 0.1a

4.8 ± 0.2b

5.0 ± 0.1b

 

 Insulin

  

14.4 ± 1.5

 

4.0 ± 0.5a

18.3 ± 2.3b

20.9 ± 2.3b

 

 Glucagon

132 ± 12

96 ± 6

  

62 ± 3a

134 ± 11b

145 ± 12b

 

 Ghrelin

  

1319 ± 180

 

1563 ± 236a

1230 ± 179b

1165 ± 130b

 

 CCK

6.3 ± 0.7

3.8 ± 0.3

  

3.5 ± 0.4a

5.4 ± 0.6b

6.2 ± 0.7b

 

 GIP

  

24.2 ± 1.3

 

10 ± 1a

31 ± 2b

31 ± 2b

 

 GLP-1

32.4 ± 3.1

21.4 ± 1.2

  

20 ± 2a

29 ± 3b

32 ± 2c

 

180min

 Glucose

5.0 ± 0.1

5.6 ± 0.2

     

5.3 ± 0.1

 Insulin

5.1 ± 1.2

7.6 ± 0.7

  

3.6 ± 0.4a

3.5 ± 0.4a

11.9 ± 1.6b

 

 Glucagon

99 ± 6

84 ± 6

  

59 ± 3a

71 ± 7b

145 ± 10c

 

 Ghrelin

  

1477 ± 253

 

1713 ± 294a

1633 ± 281a

1085 ± 194b

 

 CCK

4.8 ± 0.5

3.1 ± 0.2

  

3.1 ± 0.3a

3.4 ± 0.4a

5.3 ± 0.4b

 

 GIP

  

19.2 ± 1.2

 

7 ± 1a

19 ± 1b

31 ± 2c

 

 GLP-1

35 ± 3

23 ± 1

  

20 ± 2a

28 ± 2b

38 ± 3c

 

C

Interaction effect

 

Men

Women

 

Control

30 g protein

70 g protein

Control

30 g protein

70 g protein

60min

 Glucagon

65 ± 5*,a

154 ± 18*,b

177 ± 15*,c

58 ± 4a

115 ± 10b

114 ± 11b

 GLP-1

23.0 ± 2.4a

35.0 ± 4.2b

39.1 ± 3.0*,b

17.2 ± 1.3a

22.5 ± 1.4,b

24.7 ± 1.4b

180min

 GIP

7.6 ± 1.7*,a

19.6 ± 1.8*,b

31.8 ± 3.7c

5.9 ± 1.9a

21.4 ± 2.2b

32.9 ± 3.9c

  1. Main gender (A) and protein-load effects (B), and interaction effects (C) of gender by protein-load for mean (± SEM) 60-min and 180-min concentrations of blood glucose (mmol/L) and plasma insulin (mU/L), glucagon (pg/mL), ghrelin (pg/mL), cholecystokinin (CCK; pmol/L), gastric inhibitory polypeptide (GIP; pmol/L) and glucagon-like peptide-1 (GLP-1; pmol/L) in healthy young men (n = 8, n = 7 for GIP and GLP-1) and women (n = 8) after control (~2 kcal) and 30 g (120 kcal) or 70 g (280 kcal) protein loads. Results are presented separately for gender or protein-load if the main effect was significant, in case of non-significance the average was presented. Interaction effects of gender by protein-load are given if the effect was significant. Effects of gender and protein-load and interaction effects were determined by using repeated measures ANOVA including baseline values at each treatment visit as a covariate and post hoc Bonferroni corrections. Post hoc effects: * P < 0.05: men vs. women; a,b,c P < 0.05: a different letter indicates a significant difference between drink-conditions within subject group.