Table 4 Univariate and multivariate linear regression models predicting LVEF (%), average GLS (%), and E/A ratio for different metabolic biomarkers, adjusted for age (years), gender, BMI (kg/m2), SBP (mmHg), DBP (mmHg), diabetes, MAFLD vs. control.

From: Metabolic biomarkers related to cardiac dysfunction in metabolic-dysfunction-associated fatty liver disease: a cross-sectional analysis

Dependent variable

Predictor

B unadjusted

(95% CI)

P-value

B adjusted

(95% CI)

P-value

LVEF (%)

LPC (18:2/0:0) × 10−6

1.244

(0.1–2.388)

0.037

0.477

(−1.685–2.639)

0.667

 

MAFLD

−3.152

(−6.205–−0.099)

0.047

−2.915

(−9.941–4.111)

0.42

LVEF (%)

LPC (22:6) × 10−5

0.45

(−1.04–1.94)

0.559

−0.47

(−2.25–1.3)

0.605

 

MAFLD

−3.15

(−6.21–−0.1)

0.047

−3.99

(−10.4–2.42)

0.231

LVEF (%)

Glycyl tyrosine × 10−6

3.148

(2.57–3.727)

<0.001

2.367

(1.34–3.394)

< 0.001

 

MAFLD

−3.152

(−6.205–−0.099)

0.047

−1.318

(−7.129–4.493)

0.658

LVEF (%)

Cer (d18:0/23:0) × 10−4

0.175

(−1.293–1.643)

0.816

−0.297

(−1.691–1.098)

0.679

 

MAFLD

−3.152

(−6.205–−0.099)

0.047

−2.344

(−8.934–4.247)

0.49

Average GLS (%)

LPC (18:2/0:0) × 10−6

0.957

(0.446–1.468)

<0.001

0.154

(−0.485–0.793)

0.639

 

MAFLD

−3.285

(−4.481–−2.088)

<0.001

−0.01

(−2.213–2.193)

0.993

Average GLS (%)

LPC (22:6) × 10−5

0.36

(−0.09–0.81)

0.126

−0.23

(−0.75–0.3)

0.403

 

MAFLD

−3.28

(−4.48–−2.09)

<0.001

0.25

(−1.95–2.45)

0.828

Average GLS (%)

Glycyl tyrosine × 10−6

0.646

(0.148–1.143)

0.013

−0.222

(−0.65–0.206)

0.313

 

MAFLD

−3.285

(−4.481–−2.088)

<0.001

0.332

(−1.583–2.247)

0.735

Average GLS (%)

Cer (d18:0/23:0) × 10−4

0.284

(−0.337–0.905)

0.375

−0.459

(−1.005–0.086)

0.107

 

MAFLD

−3.285

(−4.481–−2.088)

<0.001

0.561

(−2.082–3.204)

0.68

E/A ratio

LPC (18:2/0:0) × 10−6

0.214

(0.122–0.306)

<0.001

0.133

(0.008–0.258)

0.042

 

MAFLD

−0.626

(−0.839–−0.412)

<0.001

0.205

(−0.13–0.539)

0.236

E/A ratio

LPC (22:6) × 10−5

0.12

(0.01–0.23)

0.043

0.02

(−0.09–0.13)

0.668

 

MAFLD

−0.63

(−0.84–−0.41)

<0.001

0.13

(−0.24–0.51)

0.494

E/A ratio

Glycyl tyrosine × 10−6

0.17

(0.092–0.247)

<0.001

0.03

(−0.066–0.125)

0.548

 

MAFLD

−0.626

(−0.839–−0.412)

<0.001

−0.054

(−0.379–0.271)

0.746

E/A ratio

Cer (d18:0/23:0) × 10−4

0.142

(0.047–0.237)

0.005

−0.001

(−0.121–0.119)

0.988

 

MAFLD

−0.626

(−0.839–−0.412)

<0.001

−0.015

(−0.447–0.416)

0.945

  1. BMI Body mass index, Cer ceramide, DBP Diastolic blood pressure, LPC lysophosphatidylcholine, LVEF Left ventricular ejection fraction, MAFLD Metabolic-dysfunction- associated fatty liver disease, SBP Systolic blood pressure.
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