Table 6 Summary of cardiometabolic impairment in male and female rats at different points in the feeding protocol.

Gender and experimental groups		Cardiometabolic impairment
		Metabolic disturbance			LV dysfunction			Cardiac autonomic imbalance			Oxidative stress			Cardiac mitochondrial impairment
		Week			Week			Week			Week			Week
		4	8	12	4	8	12	4	8	12	4	8	12	4	8	12
Male	M-NDS
	M-ORX				√	√	√	√	√	√	√	√	√	√	√	√
	M-HFS		√	√		√	√		√	√		√	√		√	√
	M-HFO		√	√	√	√	√	√	√	√	√	√	√	√	√	√
Female	F-NDS
	F-OVX		√	√			√			√			√			√
	F-HFS		√	√			√			√			√			√
	F-HFO		√√	√√		√	√		√	√		√	√√		√	√

M-NDS male normal diet sham, M-ORX male orchiectomy, M-HFS male high-fat diet sham, M-HFO male high-fat diet with orchiectomy, F-NDS female normal diet sham, F-OVX female ovariectomy, F-HFS female high-fat diet sham, F-HFO female high-fat diet with ovariectomy.

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