Table 1 Metabolic parameters in fasted blood plasma and in liver, organs weight and blood pressure of control and fa/fa group before treatment (32 weeks of age) and at the end of experiment (40 weeks of age) in control saline and fa/fa treated with saline or palm11-PrRP31.

From: Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances

Age

32 weeks

40 weeks

Group

Control

fa/fa

Control saline

fa/fa saline

fa/fa palm11-PrRP31

BW (g)

441 ± 9

572 ± 11****

456 ± 9

592 ± 18***

572 ± 26

Glucose (mmol/l)

4.95 ± 0.13

5.38 ± 0.06**

4.73 ± 0.05

5.29 ± 0.14**

5.91 ± 0.16#

TG (mmol/l)

1.11 ± 0.08

4.30 ± 0.28****

1.24 ± 0.15

6.78 ± 1.15***

5.09 ± 0.74

CHOL (mmol/l)

3.37 ± 0.27

7.83 ± 0.51****

2.08 ± 0.15

3.77 ± 0.22****

3.75 ± 0.27

FFA (mmol/l)

0.66 ± 0.04

0.58 ± 0.04

1.79 ± 0.10

1.42 ± 0.18

1.53 ± 0.18

Leptin (ng/ml)

4.02 ± 0.61

46.55 ± 1.61****

3.74 ± 0.51

46.80 ± 1.90****

49.57 ± 2.20

Insulin (ng/ml)

0.49 ± 0.06

1.24 ± 0.02****

0.27 ± 0.06

1.04 ± 0.11***

1.38 ± 0.18

QUICKI

  

0.374 ± 0.013

0.296 ± 0.005****

0.283 ± 0.004

Liver (g)

  

15.00 ± 0.65

23.14 ± 0.70****

21.50 ± 0.71

Heart (g)

  

1.10 ± 0.03

1.19 ± 0.04

1.16 ± 0.03

Kidney (g)

  

3.18 ± 0.16

3.46 ± 0.16

3.34 ± 0.15

MAP (mmHg)

  

105.75 ± 6.39

117.67 ± 7.01

125.13 ± 1.57

HR (beat/min)

  

389.05 ± 13.00

371.07 ± 38.80

378.80 ± 16.37

  1. Data are presented as means ± SEM. Statistical analysis was performed by t-test or one-way ANOVA (32 weeks).
  2. Significance is *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 by t-test fa/fa vs. control (n = 7–8 before the treatment) and one-way ANOVA fa/fa saline vs. control saline (n = 7–8 at the end of experiment), #P < 0.05 fa/fa palm11-PrRP31 vs. fa/fa saline (n = 8 at the end of experiment).
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