Table 1 General information of 15 studies included (gray and white matter).
Study | Participants (female) | Neuropsychology examinations | Age means (sd.) | P value | Disease duration (year) | Field strength (T) | T2DM HbA1c (%) | T2DM BMI (kg/m2) | Coordinate space | Subject | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | T2DM | HC | T2DM | HC | |||||||||
Moran et al. [39] | 713 (308) | 350 (140) | 363 (168) | Other | 67.8 (6.90) | 72.1 (7.20) | 0.001 (corrected) | NA | 1.5 | 7.20 | 31.30 | NO | Gray matter |
Li et al. [14] | 56 (35) | 28 (15) | 28 (20) | MoCA + MMSE | 56.5 (1.10) | 53.9 (1.20) | 0.05 (corrected) | 8.20 | 3.0 | 9.80 | 24.80 | MNI | Gray matter |
Chen et al. [35] | 22 (16) | 11(8) | 11(8) | MMSE | 61.2 (NA) | 56.2 (NA) | 0.05 (corrected) | NA | 3.0 | 8.30 | 25.40 | MNI | Gray matter |
Natalia et al. [42] | 50 (19) | 25 (8) | 25 (11) | MMSE + Other | 60.0 (4.60) | 57.8 (5.40) | 0.001 (uncorrected) | NA | 3.0 | 6.67 | 28.60 | TAL | Gray matter |
Wang et al. [11] | 46 (16) | 23 (7) | 23 (9) | MoCA + MMSE + Other | 53.1 (9.60) | 53.9 (9.20) | 0.001 (uncorrected) | 7.00 | 3.0 | 8.30 | 25.90 | MNI | Gray matter |
Yoon et al. [16a] | 150 (75) | 100 (50) | 50 (25) | Other | 49.2 (7.70) | 49.0 (7.80) | 0.05 (corrected) | 1.83 | 1.5 | 7.12 | 25.50 | TAL | Gray matter |
Zhang et al. [37] | 57 (37) | 29 (17) | 28 (20) | MoCA + MMSE | 56.21 (7.69) | 52.24 (9.09) | 0.05 (corrected) | 8.18 | 3.0 | 7.78 | 24.35 | MNI | Gray matter |
Zhou et al. [38] | 40 (20) | 21 (11) | 19 (9) | MMSE + Other | 68 (5.00) | 69 (5.00) | 0.001 (uncorrected) | 4.70 | 1.5 | 8.60 | 25.70 | TAL | Gray matter |
Wei et al. [25] | 63 (30) | 31 (15) | 32 (15) | MMSE | 58.42 (8.42) | 55.03 (7.81) | 0.001 (uncorrected) | 5.73 | 1.5 | 6.77 | 26.30 | MNI | Gray matter |
Duan et al. [36] | 104 (44) | 52 (18) | 52 (26) | MoCA + MMSE + Other | 54.35 (5.33) | 53.31 (4.30) | 0.05 (corrected) | 9.19 | 3.0 | 8.42 | 24.32 | MNI | Gray matter |
Feng et al. [40] | 40 (NA) | 20 (NA) | 20 (NA) | MoCA + Other | 36.45 (3.72) | 34.05 (4.78) | 0.05 (corrected) | 3.79 | 3.0 | 9.80 | 25.41 | MNI | Gray matter |
Cui et al. [46] | 80 (45) | 38 (18) | 42 (27) | MMSE + Other | 60.2 (7.4) | 58.2 (6.4) | 0.05 (corrected) | 9.0 | 3.0 | 8.00 | 24.90 | MNI | White matter |
Kim et al. [43] | 40 (22) | 20 (11) | 20 (11) | Other | 54.6 (2.3) | 54.3 (2.4) | 0.05 (corrected) | 12.1 | 3.0 | 10.70 | 24.70 | MNI | White matter |
Xiong et al. [44] | 48 (30) | 20 (12) | 28 (18) | MMSE + MoCA + Other | 63.55 (5.81) | 59.65 (5.98) | 0.01 (corrected) | 9.09 | 3.0 | 8.15 | 24.37 | MNI | White matter |
Yau et al. [45] | 41 (20) | 24 (11) | 17 (9) | Other | 57.21 (8.05) | 56.44 (6.94) | 0.01 (corrected) | 7.94 | 1.5 | 7.83 | 32.13 | TAL | White matter |
Yoon et al. [16]a | 150 (75) | 100 (50) | 50 (25) | Other | 49.2 (7.70) | 49.0 (7.80) | 0.05 (corrected) | 1.83 | 1.5 | 7.12 | 25.50 | MNI | White matter |
