Table 3 Mediation effects of dietary sodium on NAFLD with CRP and red cell distribution width as mediators.

From: Potential role of inflammation in relation to dietary sodium and β-carotene with non-alcoholic fatty liver disease: a mediation analysis

 

Without adjustment for β-carotene

With adjustment for β-carotene

 

Estimatesa

95% CIs

P-values

Estimatesb

95% CIs

P-values

HSI-defined NAFLD

CRP

 Total effect

0.0662

0.0497–0.0862

<0.0001

0.0683

0.0492–0.0844

<0.0001

 Direct effect

0.0605

0.0402–0.0788

<0.0001

0.0633

0.0432–0.0775

<0.0001

 Indirect effect

0.0057

0.0021–0.0091

<0.0001

0.0050

0.0021–0.0083

<0.0001

Red cell distribution width

 Total effect

0.0675

0.0483–0.0883

<0.0001

0.0676

0.0534–0.0826

<0.0001

 Direct effect

0.0663

0.0478–0.0869

<0.0001

0.0665

0.0529–0.0819

<0.0001

 Indirect effect

0.0012

0.0002–0.0027

<0.0001

0.0011

0.0002–0.0022

0.0400

FLI-defined NAFLD

CRP

 Total effect

0.0686

0.0374–0.1010

<0.0001

0.0752

0.0481–0.1072

<0.0001

 Direct effect

0.0605

0.0322–0.0918

<0.0001

0.0680

0.0402–0.0992

<0.0001

 Indirect effect

0.0081

0.0024–0.0162

<0.0001

0.0072

0.0009–0.0121

<0.0001

Red cell distribution width

 Total effect

0.0701

0.0383–0.0981

<0.0001

0.0747

0.0501–0.1072

<0.0001

 Direct effect

0.0692

0.0384–0.0967

<0.0001

0.0739

0.0490–0.1071

<0.0001

 Indirect effect

0.0009

−0.0001 to 0.0027

0.0800

0.0008

−0.0004 to 0.0019

0.2000

  1. CI confidence interval, CRP c-reactive protein, FLI fatty liver index, HSI hepatic steatosis index.
  2. aAdjusted for age, sex, ethnicity, education level, family monthly poverty level, smoking, drinking, sedentary time, total energy intake, dietary inflammatory index, and serum creatinine.
  3. bAdjusted for age, sex, ethnicity, education level, family monthly poverty level, smoking, drinking, sedentary time, total energy intake, dietary inflammatory index, serum creatinine, and dietary β-carotene.