Fig. 4: Melatonin increases adaptive thermogenesis of cold-stimulated mice.

A Rectal temperature of 22 °C- and 4 °C-stimulated mice. B UCP1-stained BAT section of 22 °C- and 4 °C-stimulated mice. C mRNA expression of thermogenesis-related genes in BAT of mice. Data are mean ± SEM, n = 4. Significance was determined by one-way ANOVA. *p < 0.05, **p < 0.01 vs. 22 °C + Veh mice; #p < 0.05, ##p < 0.01, vs. 4 °C + Veh mice.