Fig. 6: Melatonin ameliorates HFD-induced insulin resistance and hepatic steatosis. | Nutrition & Diabetes

Fig. 6: Melatonin ameliorates HFD-induced insulin resistance and hepatic steatosis.

From: Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet

Fig. 6

A Glucose tolerance test. B Insulin tolerance test. C Blood glucose and plasma insulin levels. D Immunoblots of phosphorylated Ser473 Akt (p-Akt) and Akt in the liver. E H&E-stained liver sections. Scale bars = 100 μm. F Hepatic lipid levels. G Plasma ALT content. H mRNA levels of lipogenesis-related and fatty acid oxidation-related genes in the liver. I The levels of FGF21 in plasma and liver of mice. Data are mean ± SEM, n = 5–8. Significance was determined by one-way ANOVA. *p < 0.05, **p < 0.01 vs. NC + Veh mice; #p < 0.05, ##p < 0.01, vs. HFD + Veh mice. AUC area under curve, TG triglyceride, TC total cholesterol, NEFA non-esterified fatty acid, ALT alanine aminotransferase.

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