Fig. 8: Loss of protection against obesity by melatonin in FGF21−/− mice. | Nutrition & Diabetes

Fig. 8: Loss of protection against obesity by melatonin in FGF21−/− mice.

From: Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet

Fig. 8

A Body weight of FGF21−/− mice on a HFD with or without melatonin. B Food intake of mice. C Fat mass and lean mass of the mice. D Tissue weights of the mice. E VO2 and VCO2 of the mice. F Rectal temperature of the mice. G mRNA levels of thermogenesis-related genes in BAT, iWAT, and eWAT. H Glucose and insulin tolerance tests. I H&E-stained eWAT and liver sections. Scale bars = 100 μm. Data are mean ± SEM, n = 5–6. Significance was determined by one-way ANOVA. *p < 0.05, **p < 0.01 vs. HFD + Veh mice.

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