Fig. 2: Diabetes negatively affected the reproductive performance of female mice.
From: Nicotinamide Mononucleotide improves oocyte maturation of mice with type 1 diabetes
A Representative images of ovaries from normal mice and the mice with diabetes. The ovarian volume of the mice with diabetes was smaller than that of normal mice. B The weight of ovaries from normal mice (n = 3) and the mice with diabetes (n = 5). The ovarian weight of the mice with diabetes was smaller than that of normal mice. C The number of GV oocytes collected from normal mice and the mice with diabetes. Compared with that in normal mice, the mice with diabetes have fewer GV oocytes. D Number of MII oocytes collected from super-ovulated normal mice and the mice with diabetes. Compared with that in normal mice, the mice with diabetes have fewer MII oocytes. E Representative images of MII oocytes collected from normal mice and the mice with diabetes. F Representative images of in vitro maturation oocytes in Control, Diabetic, and Dia + NMN group. G The in vitro maturation rate of oocytes in Control, Diabetic, and Dia + NMN group. The in vitro maturation rate of GV oocytes in the mice with diabetes was significantly reduced, and NMN supplementation in the culture medium significantly increased the in vitro maturation rate. **P < 0.01; ****P < 0.0001.
