Table 3 Interaction analysis of Hp genotype and Hb level for GDM risk.

From: First-trimester hemoglobin, haptoglobin genotype, and risk of gestational diabetes mellitus in a retrospective study among Chinese pregnant women

Group

Hp1 carrier

Hp2–2

Effect of Hp genotype stratified by Hb

Hb ≤122 g/L

1 [Reference]

0.655 (0.283–1.516)

0.655 (0.283–1.516)

Hb >122 g/L

1.459 (0.791–2.690)

4.587 (2.572–8.179)

3.144 (1.717–5.755)

Effect of Hb stratified by Hp genotype

1.459 (0.791–2.690)

7.005 (3.034–16.174)

 

Multiplicative scale

4.801 (1.705–13.517)

  

RERI

3.472 (1.629–6.697)

  

AP

0.757 (0.425–0.936)

  

SI

31.542 (1.001–789089)

  
  1. RERI Relative excess risk due to interaction, AP Attributable proportion due to interaction, SI the synergy index.
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