Table 1 Mouse tumors expression data reveal the Etv5 transcription factor as a good candidate for Ret regulation

From: Activated ALK signals through the ERK–ETV5–RET pathway to drive neuroblastoma oncogenesis

Symbol

Mean MYCN

Mean MYCN/ALKmut

P-value

Fold-change

Ret

5.4

8.4

3.99E−05

8.4

Egr1

8.6

9.2

NS

1.6

Hoxb5

2.4

2.3

NS

−1.1

Nkx2-1

2

2

NS

1

Pax3

2.4

2.4

NS

1

Sox10

2.7

2.7

NS

1

Sp1

8.2

7.8

2.34E−02

−1.3

Sp3

11.4

11.1

3.73E−02

−1.2

Ebf3

3.3

7.2

2.88E−06

14.3

Mycn

5.5

8.1

9.20E−06

6.1

Etv5

4.2

6.4

1.52E−07

4.5

Zfp939

3.1

5.3

4.83E−02

4.4

Hmx1

1.9

3.8

5.55E−03

3.8

  1. The mean expression of genes (log2 values obtained with expression arrays) in murine MYCN (n = 10) and MYCN/Alkmut tumors (n = 11 MYCN/AlkF1178L and n = 10 MYCN/AlkR1279Q) is indicated together with the P-value (corrected by the Benjamini–Hochberg method) and the fold-change of a differential analysis (two-sided Welch’s t-test). Top: the previously identified Ret gene; middle: the transcription factors described in literature as regulating RET expression; bottom: the top 5 transcription factors differentially overexpressed in MYCN/Alkmut tumors compared to MYCN tumors. NS not significant (P-value > 0.05)
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