Fig. 5 | Oncogene

Fig. 5

From: Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer

Fig. 5

Schematic representation of SRC-1 signalling cascade. SRC-1 interacts with STAT1 at the promoter region of E2F7, NFIA, SMAD2, and ASCL1. Expression of these TFs promotes an endocrine resistant phenotype in breast cancer. Downstream network analysis revealed perturbations in several pathways involved in cancer progression including, cell differentiation, cell cycle and pathways in cancer

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