Table 1 Enriched pathways in 46 commonly differentially expressed genes from RNA-Seq and CCLE microarray data

From: Ibrutinib inhibition of ERBB4 reduces cell growth in a WNT5A-dependent manner

ID

Term

P-value

Genes

GO:0016055

Wnt receptor signaling pathway

0.0009

WNT5A, TBL1XR1, DKK1, TLE2

GO:0009411

Response to UV

0.0009

ERCC8, HUS1, GTF2H2

GO:0009628

Response to abiotic stimulus

0.0011

ARSB, ERCC8, SNN, HUS1, COL3A1, GTF2H2

GO:0035113

Embryonic appendage morphogenesis

0.0028

WNT5A, DKK1, SMARCA4

GO:0030326

Embryonic limb morphogenesis

0.0028

WNT5A, DKK1, SMARCA4

GO:0009314

Response to radiation

0.0040

ERCC8, HUS1, COL3A1, GTF2H2

GO:0035107

Appendage morphogenesis

0.0041

WNT5A, DKK1, SMARCA4

GO:0035108

Limb morphogenesis

0.0041

WNT5A, DKK1, SMARCA4

GO:0048736

Appendage development

0.0045

WNT5A, DKK1, SMARCA4

GO:0060173

Limb development

0.0045

WNT5A, DKK1, SMARCA4

REACT_216

DNA repair

0.0060

ERCC8, RAD50, GTF2H2

GO:0051052

Regulation of DNA metabolic process

0.0060

ERCC8, HUS1, RAD50

GO:0033554

Cellular response to stress

0.0094

SLC11A2, WNT5A, ERCC8, HUS1, RAD50, GTF2H2

GO:0009416

Response to light stimulus

0.0100

ERCC8, HUS1, GTF2H2

  1. Enriched pathway terms identified by DAVID tools are ranked based on P-values from the Fisher’s exact test. P-values (raw and adjusted values by the Benjamini–Hochberg method) from the EASE test and gene names in each term are also shown