Fig. 5
From: Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
CDK2 inhibition is responsible for dephosphorylation and suppression of MYC in human Group 3 tumor cells. a Protein levels of total MYC, p-T58 MYC, p-S62 MYC, p53, and cleaved caspase 3 in 24 h treated MB002 cells. b Forty-eight-hour DOX-induction of transduced MB002 with shRNA targeting CDK2 or non-targeting control. Verification of downregulated CDK2 expression using western blot. c Survival of MB002 cells after 72 h DOX induction of shRNA CDK2 (shCDK2) or non-targeting shRNA control (shCtrl). d Survival of MB002 cells after 72 h DOX induction of shCtrl and shCDK2.1 alone or together with JQ1 (500 nM) or Milciclib (500 nM)
