Fig. 7
From: Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
Dual BET and CDK2 inhibition of orthotopically grafted Group 3 tumors leads to a significantly prolonged survival. a Kaplan–meier survival curve of GTML2 xenografts treated with 7 doses of JQ1 or Milciclib or a combination of the two. b Bioluminescence measurement (luminescence) of luciferase in GTML2-transplanted mice from the start of treatment until the end of experiment (EoE). c Tumor growth was monitored using luciferase expression in transplanted cells during the course of treatment of GTML2 xenografts. The tumor area (mm2) was calculated based on luciferase signal from the NightOWL IVIS (Berthold) and analyzed using the Indigo software. d Kaplan–Meier survival curve of MB002 xenografts treated with seven doses of JQ1, Milciclib, or a combination of both compounds. Kaplan–meier curve statistical analysis: LogRank (Mantel–Cox test); luminescence and tumor burden statistical analysis: Student’s t-test
