Fig. 2
In vivo potency of BI 894999 and HEXIM1 modulation in AML xenografts. a Kaplan–Meier curve of CIEA-NOG mice intravenously injected with 1 × 107 MV-4-11B AML cells shows prolonged survival of animals daily treated with 2 mg/kg (light blue) or 4 mg/kg (blue) BI 894999 compared to vehicle (gray line). b Tumor volumes of NMRI-nude mice carrying MV-4-11B s.c. xenografts daily treated with either vehicle control (gray), 2 mg/kg (light blue), 4 mg/kg (blue), or 12 mg/kg (dark blue) BI 894999. c Hexim1/HEXIM1 modulation in the blood (red) and tumors (blue) of mice from the respective treatment groups in the experiment shown in Fig. 2b, measured on the indicated days of treatment
