Fig.1 | Oncogene

Fig.1

From: How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations

Fig.1

Exposure to asbestos alters the profile of cell populations in peritoneal lavage. a Experimental scheme: 6–8-week-old C57Bl/6J mice were exposed to crocidolite i.p. (400 µg/mouse) every 3 weeks with in total eight treatments. Thirty-three weeks after initial exposure to crocidolite mice were sacrificed to collect peritoneal lavage, blood, and tissues. Tumor-bearing mice were sacrificed to collect tumor tissue. b The lavage from crocidolite-exposed mice shows higher proportions of macrophages and mesothelial precursor populations as compared to sham-exposed mice. Flow-cytometry analysis of samples is shown in the left panel. A significant decrease in the total number of T and B cells was observed in the peritoneal lavage 12 weeks after last exposure to crocidolite. c The proportion of T cells was significantly increased in the spleen of asbestos-exposed mice. No difference for B cells was observed in the spleen. N = 6–8 mice. Mean ± SE. *p < 0.05, **p < 0.01, Mann–Whitney test

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