Fig. 1 | Oncogene

Fig. 1

From: Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7–CYFIP1-mediated signaling pathway

Fig. 1

GAS7b mRNA expression level is lower in early onset breast cancer samples. a The mRNA expression levels of four isoforms (GAS7a, GAS7b, GAS7c, and GAS7d) of GAS7 in 16 pairs of breast normal/tumor tissue specimens were analyzed by RT-qPCR. b GAS7b mRNA expression levels in 30 pairs of breast normal/tumor tissue specimens were analyzed by paired t-test. c GAS7c mRNA expression levels in 29 pairs of breast normal/tumor tissue specimens were analyzed by paired t-test. d GAS7b mRNA expression levels between early onset breast cancer patients (age ≤ 40 years old, n = 78) and older patients (age > 40 years old, n = 118) were analyzed. e GAS7b mRNA expression levels for tumors of earlier (stages 0+I+II, n = 113) versus latter stages (stages III+IV, n = 62) were analyzed. f GAS7b mRNA expression levels for early (n = 42) and late (n = 27) tumor stages within the ≤40 year-old age group were analyzed. Two-tailed t-test was used for statistical analysis (**p < 0.01; ***p < 0.001; n.s. non-significant)

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