Fig. 5
From: LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy
Lysyl oxidase activity impairs response toward cytotoxic chemotherapeutics in primary tumors and lung metastases. a Treatment of established 4T1 control and 4T1 LOX/LOX2 OE BCAs with DOX. b Weight of treated 4T1 control and 4T1 LOX/LOX2 OE BCAs 26 days after implantation. c Treatment of established EMT6 BCAs with βAPN and DOX. Although βAPN did not reduce tumor growth of EMT6 BCAs, it increased response to DOX. d Size distribution of EMT6 BCAs after treatment. e Treatment of established LLC tumors with βAPN and CDDP. f Weight of treated LLC tumors 18 days after implantation. Combination of βAPN and CDDP significantly reduced tumor size. Error bars: ±SEM. * indicates statistical significance vs. control, # indicates statistical significance of combination treatment group vs. both single treatment groups: *,#P < 0.05, **, ##P < 0.01, ***P < 0.001
