Fig. 3

High Notch3⁺CXCR4⁺DP T-cells in circulating blood of N3-ICtg mice. a CD4/CD8 flow-cytometry analysis of blood from WT (n = 3) and N3-ICtg (n = 3) mice (3-week old). b Left: representative plots of CD4⁺CD8⁺ circulating in 6–8 and 12–14-week-old WT (n = 4) and N3-ICtg (n = 4) blood; Right: Notch3⁺CXCR4⁺ within DP-gated T-cells. The average percentages ± SD of three to four analyzed animals are indicated. c Ratio of the percentages of Notch3⁺CXCR4⁺ as fold over Notch3⁻CXCR4⁺ in DP-gated cells in N3-ICtg mice. For each corresponding age, at least four N3-ICtg mice were analyzed. (*p<0.05; **p<0.01; ****p < 0.0001; ns, not significant; One-way ANOVA-test). See also Figure S2