Fig. 6
From: Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation
In vivo CXCR4 antagonism greatly contrast atypical DP infiltration in N3-ICtg BM. Three- to four-week-old N3-ICtg mice were treated daily with PBS (PBS) or with the CXCR4 antagonist, AMD3100. At day10 post-injection, absolute numbers a of DP T-cells and b of Notch3+CXCR4+DP T-cells were analyzed. PBS, n = 3; AMD3100, n = 6. Results represent mean ± SD (*p < 0.05; **p < 0.01; Student’s t-test)
