Fig. 3 | Oncogene

Fig. 3

From: Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer

Fig. 3

Suppression of ERRα reduces T:E fusion or ERG expression and ERG-mediated signaling in AR-positive VCaP cells. (a, c) mRNA and (b, d) protein expressions of T:E fusion/ERG in VCaP cells upon XCT790 treatment or ERRα knockdown by shRNA. Both mRNA and protein levels of T:E fusion/ERG were significantly reduced by XCT790 treatment in a dose-dependent manner (1–20 µM) and also shERRα. (e, f) mRNA levels of ERG-responsive targets were significantly suppressed by either XCT790 or shERRα. *P < 0.05; **P < 0.01 versus vehicle treatment or Scramble shRNA transfection

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