Fig. 5 | Oncogene

Fig. 5

From: FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p

Fig. 5

FGF18 is directly regulated by miR-590-5p in GC. a The putative binding site of miR-590-5p was located in the FGF18 3′ UTR according to miRNA database miRDB. b Both mRNA and protein expression of FGF18 were decreased after miR-590-5p overexpression in AGS and MKN28 cells (**, P < 0.001). c miR-590-5p suppressed the luciferase activity in the constructs containing the wild-type binding site in 3′ UTR of FGF18 (**, P < 0.001), but without effect in the constructs containing a corresponding mutated binding site. d The expression association between FGF18 mRNA and miR-590-5p in TCGA cohort. e The expression pattern of miR-590-5p in 11 GC cell lines and an immortalized gastric epithelium cell line GES-1. All GC cell lines showed a uniform decrease of miR-590-5p. Dash line indicated the normalized expression of miR-590-5p in GES-1

Back to article page