Fig. 7 | Oncogene

Fig. 7

From: Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition

Fig. 7

Cancer cells underwent cell apoptosis and senescence after acute exposure of high-dose IR, CDC6 protein level elevated. Cancer cells underwent premature senescence and EMT, and developed radioresistance after long-term exposure of low-dose IR. CDC6 expression significantly elevated in the radioresistant cancer cells. Ectopic elevation of CDC6 in cancer cells induced premature senescence and EMT, which are similar characteristics the radioresistant cancer cells exhibited. Conversely, the depletion of CDC6 in the radioresistant cancer cells promoted cancer cells to typical senescence from premature senescence, reversed EMT and promoted cell apoptosis. Eventually, CDC6 depletion sensitized radioresistant xenografts to IR, resulting in significant tumor regression

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