Fig. 6
Tamoxifen treatment inhibits HSC durotaxis via GPER signalling. a Average cell movement distance on the soft-stiff rigidity gradient compared to single rigidity soft and stiff substrates presented as an average displacement (positive values indicate directed movement towards stiff substrate, negative values towards soft substrate and 0 indicates random movement. n = 3 independent experiments. b Cell movement speed on the soft-stiff rigidity gradient compared to single rigidity soft and stiff substrates. c Representation of the average displacements of HSCs. Quantification was done for 75 cells. Three experimental replicates in all cases. Results are expressed as mean ± sem. Anova and Tukey’s post hoc tests were used for the analysis
