Fig. 4

a Gene Ontology (GO) term enrichment analysis (Biological Process) performed on genes downregulated (white) and upregulated (gray) upon circ-ZNF609 depletion in RD cells (upper panel) and RH4 cells (lower panel). For RH4 cells, there was not any enriched category for upregulated genes. b msVIPER analysis plot for RD cells (left) and RH4 cells (right) showing the transcriptional status (blue = repressed, red = activated) of the target genes for each differentially active transcriptional regulator (genes are represented by vertical bars in each horizontal row), drawn using the plot.msviper function. The right side of the figure displays the inferred differential activity (first column, red = activated and blue = de-activated) and expression (second column, gray = not expressed and white = expressed), with the rank of the displayed genes in the VIPER inferred gene expression signature (numbers at the right side of the plot). p-values refer to the differential activity of the factor calculated by msVIPER