Fig. 8 | Oncogene

Fig. 8

From: Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness

Fig. 8

Summary of established DICER1-miRNA regulatory network in thyroid cancer. Overexpressed (oncogenic) miRNAs in thyroid cancer target DICER1. miR-146b (bold) directly binds to DICER1 3′UTR; other miRNAs (grey) have a predicted biding site in DICER1 3′UTR. Also, DICER1 upregulates tumor suppressor miRNAs, which in turn inhibit proliferation, migration, invasion, and EMT. This effect can be phenocopied when increasing the DICER1 complex activity with the small-molecule enoxacin. The arrows denote induction and the truncated lines repression

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