Fig. 8 | Oncogene

Fig. 8

From: HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells

Fig. 8

Model of SE-associated gene regulation by HDAC1/3-HDAC7 axis in CSCs. The cumulative results of our experiments with HDAC1/3/7 inhibitor MS-275 (Entinostat) as well as HDAC1-, HDAC3-, and HDAC7-specific siRNAs are depicted in a mechanistic model. The direct repressive activity of HDAC1 and HDAC3 is shown by “MS-275 activated genes”. In addition to this well-known activity, our results indicate a novel HDAC1/3 mechanism through HDAC7, which in turn maintains H3K27ac and expression of BrCa relevant, SE-associated oncogenes such as c-MYC, CD44, CDKN1B, BCL-XL, SLUG, VDR, VEGFA, and SMAD3. [18, 42] Importantly, this HDAC1/3-HDAC7 axis is only active in stem-like cells and not in other cells

Back to article page