Fig. 1 | Oncogene

Fig. 1

From: Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors

Fig. 1

Implanted malignant peripheral nerve sheath tumor (MPNST) cells form quantifiable mass in the pericardial cavity of zebrafish embryos. a Injected mCherry-labeled primary MPNST cells expand under dimethyl sulfoxide (DMSO) treatment in vivo. Right panels show enlarged views to areas outlined by white boxes (left). White arrows indicate injected tumor cells; the asterisk denotes autofluorescence from gut. b Quantification of implanted tumor cell growth. Each dot represents a cross-sectional red fluorescent area (pixel) of each embryo; bars indicate median values. *p = 0.013, ***p = 0.0008, ****p < 0.0001 (n = 4, Student’s t-test)

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